CD8+ T cells modulate autosomal dominant polycystic kidney disease progression

Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent inherited nephropathy. To date, therapies alleviating the disease have largely focused on targeting abnormalities in renal epithelial cell signaling. ADPKD has many hallmarks of cancer, where targeting T  cells has brought novel therapeutic interventions. However, little is known about the role and therapeutic potential of T cells in ADPKD. Here, we used an orthologous ADPKD model, Pkd1 p.R3277C (RC), to begin to define the role of T cells in disease progression.

Source: Kidney International - September 21, 2018 Category: Urology & Nephrology Authors: Emily K. Kleczko, Kenneth H. Marsh, Logan C. Tyler, Seth B. Furgeson, Bonnie L. Bullock, Christopher J. Altmann, Makoto Miyazaki, Berenice Y. Gitomer, Peter C. Harris, Mary C.M. Weiser-Evans, Michel B. Chonchol, Eric T. Clambey, Raphael A. Nemenoff, Katha Tags: Basic Research Source Type: research