GSE104797 Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity

Contributors : Mona L öffler ; Alexander E Mayer ; Jonathan Trujillo ; Carsten P Ade ; Till Karwen ; Sudha Janaki-Raman ; Anja Slotta ; Rabih El-Merahbi ; Angel Loza Valdes ; Manuela Erk ; Nuria Matesanz ; Jorge L Torres ; Miguel Marcos ; Guadalupe Sabio ; Almut Schulze ; Martin Eilers ; Grzegorz SumaraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDAG-activated Pkd1 promotes triglyceride accumulation in adipocytes; Pkd1 promotes lipogenesis and suppresses mitochondrial function in adipocytes in an AMPK-dependent manner; Pkd1 suppresses expression of genes characteristic for beige adipocytes; Deletion of Pkd1 in adipocytes protects mice from diet-induced obesity, T2D and liver steatosis.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research