Synthesis of 28,28,28-trideutero-25-hydroxydihydrotachysterol2

Publication date: Available online 19 September 2018Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Rita Sigüeiro, Julian Loureiro, Patricia González-Berdullas, Antonio Mouriño, Miguel A. MaestroAbstractAs part of our program on synthesis of labeled vitamin D metabolites and analogs, we describe here an efficient and versatile synthetic approach to 28,28,28-trideutero- 25-hydroxydihydrotachysterol2 where isotopic labeling was incorporated stereoselectively in the last step of the synthesis. This deuterated compound will allow the study this analog in vitro or in vivo and to measure AT10-like compounds in serum by LC-MS/MS.Graphical Abstract
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research