Cancers, Vol. 10, Pages 338: Phase I Study of Carbon Ion Radiotherapy and Image-Guided Brachytherapy for Locally Advanced Cervical Cancer

Cancers, Vol. 10, Pages 338: Phase I Study of Carbon Ion Radiotherapy and Image-Guided Brachytherapy for Locally Advanced Cervical Cancer Cancers doi: 10.3390/cancers10090338 Authors: Tatsuya Ohno Shin-ei Noda Kazutoshi Murata Yuya Yoshimoto Noriyuki Okonogi Ken Ando Tomoaki Tamaki Shingo Kato Takashi Hirakawa Tatsuya Kanuma Takashi Minegishi Takashi Nakano on behalf of the Working Group for Gynecologic Cancer A phase I study was performed to determine the recommended dose of carbon ion radiotherapy and 3D image-guided brachytherapy for histologically confirmed stage II (≥4 cm), III, or IVA cervical cancer. Dose-limiting toxicities (treatment-related toxicities occurring within three months from the start of carbon ion radiotherapy) included Grade 3 non-hematological toxicity, Grade 4 hematological toxicity, or interruption of treatment for more than two weeks due to treatment-related toxicities. Carbon ion radiotherapy consisted of whole-pelvic irradiation with 36.0 Gy (relative biological effectiveness) in 12 fractions and local boost with 19.2 Gy in four fractions for the primary site, and for positive lymph nodes. Three sessions of three-dimensional (3D) image-guided brachytherapy were administered after completion of carbon ion radiotherapy. Weekly cisplatin at a dose of 40 mg/m2 was given concurrently. At a dose level of one, a total rectosigmoid D2cc dose between 67.2 Gy and 71.3 Gy at a biological equivalent dose of 2 Gy per fraction...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research