The impact of patient choice on survival in chronic thromboembolic pulmonary hypertension

Pulmonary endarterectomy (PEA) is the gold standard treatment for operable chronic thromboembolic pulmonary hypertension (CTEPH). However, a proportion of patients with operable disease decline surgery. There are currently no published data on this patient group. The aim of this study was to identify outcomes and prognostic factors in a large cohort of consecutive patients with CTEPH. Data were collected for consecutive, treatment-naive CTEPH patients at the Pulmonary Vascular Disease Unit of the Royal Hallamshire Hospital (Sheffield, UK) between 2001 and 2014. Of 550 CTEPH patients (mean±sd age 63±15 years, follow-up 4±3 years), 49% underwent surgery, 32% had technically operable disease and did not undergo surgery (including patient choice n=72 and unfit for surgery n=63), and 19% had inoperable disease due to disease distribution. The 5-year survival was superior in patients undergoing PEA (83%) versus technically operable disease who did not undergo surgery (53%) and inoperable due to disease distribution (59%) (p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary vascular disease Original Articles: Pulmonary vascular diseases Source Type: research

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Merck and Bayer have been granted FDA Breakthrough Device Designation for the collaborative Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Artificial Intelligence Pattern Recognition software. CTEPH can be difficult to diagnose because its symptoms are similar to asthma and chronic obstructive pulmonary disease symptoms. CTEPH affects five people per million annually worldwide. Computed tomography pulmonary angiography and a ventilation/perfusion scan can be used to determine if thromboembolic occlusion is causing pulmonary hypertension in patients. Get the full story on our sister site, Medical Design &Outsourc...
Source: Mass Device - Category: Medical Devices Authors: Tags: Food & Drug Administration (FDA) Bayer Merck Source Type: news
Edwards Lifesciences is delving deeper into the realm of artificial intelligence through a partnership with San Francisco-based Bay Labs. The goal of the collaboration, which has multiple initiatives is to improve the detection of heart disease. Some of the initiatives include, the development of new AI-powered algorithms in Bay Labs’ EchoMD measurement and interpretation software suite; support for ongoing clinical studies at institutions; and the integration of EchoMD algorithms into Edwards Lifesciences’ CardioCare quality care navigation platform. Irvine, CA-based Edwardsâ€...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Cardiovascular Source Type: news
Harry Karmouty-Quintana, Christophe Guignabert, Grazyna Kwapiszewska, Mark L. Ormiston
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusion This study demonstrates for the first time decreased NOSIP expression in the pulmonary vasculature of the nitrofen-induced CDH. These findings suggest that NOSIP underexpression may interfere with NO production, contributing to abnormal vascular remodeling and PPH. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: European Journal of Pediatric Surgery - Category: Surgery Authors: Tags: Original Article Source Type: research
Publication date: Available online 8 December 2018Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): Fernanda Blasina, Lucía Vaamonde, Fernando Silvera, Gonzalo Solla, Juan Andrés Abin-Carriquiry, Carmen Gutiérrez, Pilar Beltramo, Irene García, Miguel MartellAbstractPersistent pulmonary hypertension of the newborn (PPHN) is a complex pathology resulting from a failure of the post-natal reduction in pulmonary vascular resistance leading to hypoxemia. The standard therapy is inhaled Nitric Oxide (NO) improving oxygenation but its availability is limited, especially in hospitals with restri...
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
ConclusionsIn patients with sepsis and septic shock, PH is common and is noted to be associated with higher short and long-term mortality. Further studies are needed to understand the mechanisms by which PH is associated with outcomes.
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
We present a case of a 58-year-old man who had suffered a gunshot wound 6.5 years prior to presentation for worsening pulmonary hypertension (PH). After diagnostic workup, the PH was attributed to a gunshot related AVF. Exercise capacity and echocardiographic parameters improved after successful ligation of the AVF. This case highlights a rare and correctable cause of PH that requires careful investigation and multidisciplinary expertise for treatment.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
The electrospraying technique provides nano and microparticles that can be used as drug delivery systems. The aims of this study were, firstly, to optimize the influent parameters of electrospraying for the manufacture of a Bosentan (BOS) nanoparticulate platform, and secondly, to evaluate its physicochemical properties and in vitrobiopharmaceutical behavior. Particles were characterized by scanning electron microscopy (SEM), powder X ‐ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetry (TG) and Fourier transformed Infrared spectroscopy (FTIR). Drug loading, encapsulation efficiency and kine...
Source: Biotechnology Progress - Category: Biotechnology Authors: Tags: Formulation and Engineering of Biomaterials Source Type: research
THE RIGHT-SIDED cardiac chambers and ancillary structures have long been neglected in the medical literature. Even though these structures continue to wear the badge of “forgotten” structures, physicians have long known the clinical implications of right-sided cardiac dysfunction. From the practical differences in treating acute right ventricular (RV) dysfunction during an acute myocardial infarction to the lessons learned from the chronic, long-term challenges posed by the use of the Fontan palliation procedure in patients with nascent or absent right-sided cardiac structures, the clinical implications of righ...
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
Publication date: February 2019Source: Journal of Veterinary Cardiology, Volume 21Author(s): E.F. Bode, M. Longo, C. Breheny, J. Del-Pozo, G.J. Culshaw, Y. Martinez-PereiraAbstractA 2-year 10-month, male neutered, crossbreed dog presented for evaluation of cyanosis and exercise intolerance. Doppler echocardiography revealed severe dilation of the right atrium and right ventricle with moderate pulmonary hypertension. Right-to-left shunting across a large ostium secundum atrial septal defect was confirmed by contrast echocardiography. Thoracic radiography revealed a vascular pattern together with cardiomegaly. Computed tomog...
Source: Journal of Veterinary Cardiology - Category: Veterinary Research Source Type: research
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