Genotype-guided Warfarin Dosing in Patients with Mechanical Valves: a Randomized Controlled Trial.

CONCLUSIONS: The genotype-guided warfarin dosing was safe and might be more efficient with respect to the time to reach a stable dose. Pharmacogenomic testing might be beneficial to identify the patients with the CYP2C9 *1/*3 and the highly sensitive responders, who were high risk subgroup of patients with mechanical heart valves.An appropriately powered study is needed to further confirm the above findings.
PMID: 30205115 [PubMed - as supplied by publisher]

Source: The Annals of Thoracic Surgery - September 8, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Xu Z, Zhang SY, Huang M, Hu R, Li JL, Cen HJ, Wang ZP, Ou JS, Yin SL, Xu YQ, Wu ZK, Zhang X Tags: Ann Thorac Surg Source Type: research