Revert the SIRT: Normalizing SIRT1 Activity in Myelodysplastic Stem Cells.

Revert the SIRT: Normalizing SIRT1 Activity in Myelodysplastic Stem Cells. Cell Stem Cell. 2018 Sep 06;23(3):315-317 Authors: Simeoni F, Somervaille TCP Abstract Myelodysplastic syndromes are hematologic malignancies with few treatment options and a propensity to transform to acute myeloid leukemia. In this issue of Cell Stem Cell, Sun et al. (2018) report that low SIRT1 levels in myelodysplastic stem cells contribute to aberrant self-renewal through enabling hyperacetylation and reduced activity of TET2. PMID: 30193128 [PubMed - in process]
Source: Cell Stem Cell - Category: Stem Cells Authors: Tags: Cell Stem Cell Source Type: research