Arrhythmogenic Cardiac Alternans in Heart Failure is Suppressed by Late Sodium Current Blockade by Ranolazine

Cardiac alternans is promoted by heart failure (HF) -induced calcium (Ca2+) cycling abnormalities. Late sodium current (INa,L) is enhanced in HF and promotes Ca2+ overload, however, mechanisms underlying an antiarrhythmic effect of INa,L blockade in HF remain unclear.

Source: Heart Rhythm - September 4, 2018 Category: Cardiology Authors: Hidehira Fukaya, Bradley N. Plummer, Joseph S. Piktel, Xiaoping Wan, David S. Rosenbaum, Kenneth R. Laurita, Lance D. Wilson Source Type: research