Carcinome rénal à cellules chromophobes : à propos de 16 cas et une revue de la littérature

ConclusionLe cancer chromophobe du rein est une entité anatomoclinique particulière, caractérisé par un pronostic favorable grâce à un grade de Fuhrman bas et sa limitation au rein.AbstractObjectiveTo determine the histo-clinical, pathological, therapeutic and prognostic characteristics of renal chromophobe carcinomas.Subjects and methodsThis is a retrospective study including 16 cases of chromophobe carcinoma among 86 renal cancers diagnosed in the Urology Department B of Rabat University Hospital between January 2011 and August 2017.ResultsThere were 12 women and 4 men. The average age of discovery was 57.5 years. They were distributed in 62.5% predominantly eosinophilic, 37.5% of mixed tumors. The nuclei are irregular and incisured. Tumor T1 (31.5%) and T2 (56.25%) were the most common. The majority of patients had a Fuhrman grade, 43.8% grade 2 and 31.2% grade 3. Only one patient had a local recurrence. The overall 5-year survival rate was 92%. A death related to the disease has been reported. Nephrectomy is the gold standard for 100% of patients. The average overall survival rate is 34.4 months.ConclusionChromophobic kidney cancer is a particular anatomo-clinical entity, characterized by a favorable prognosis due to a low Fuhrman grade and its limitation to the kidney.
Source: African Journal of Urology - Category: Urology & Nephrology Source Type: research

Related Links:

ConclusionBenefit/risk profile of nivolumab in Eastern-Spanish real-world population with mRCC after tyrosine-kinase inhibitors was consistent with prior real-life studies reported as well as pivotal study.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
AbstractPurpose of ReviewDue to the rapidly changing field of kidney cancer therapeutics, addressing the state of the art systemic therapy regimens, and sequencing with cytoreductive nephrectomy are the primary focus of this review. We will also discuss the role of biomarkers and novel therapeutic targets in the management of renal cell carcinoma.Recent FindingsThe management of metastatic renal cell cancer has undergone a paradigm shift with immune checkpoint inhibitors being used in the frontline setting. Over the last 4  years, programmed cell death-1 (PD-1) inhibitors as well as programmed cell death ligand-1 inhi...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
The aim of this Chinese study was to evaluate the influencing factors of perioperative renal function change and their relationship with prognosis in patients with renal cell carcinoma and tumor thrombus after nephrectomy and thrombectomy.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
ConclusionAfrican-American race is associated with prolonged survival in non-ccmRCC, but it is also associated with lower survival rates in ccmRCC. The exception to these observations consisted of patients treated with combination of CNT  + ST for either ccmRCC or non-ccmRCC.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
AbstractIn this article, we review de state of the art on the management of renal cell carcinoma (RCC) and provide recommendations on diagnosis and treatment. Recent advances in molecular biology have allowed the subclassification of renal tumours into different histologic variants and may help to identify future prognostic and predictive factors. For patients with localized disease, surgery is the treatment of choice with nephron-sparing surgery recommended when feasible. No adjuvant therapy has demonstrated a clear benefit in overall survival. Considering the whole population of patients with advanced disease, the combin...
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: XGP is a diagnostic and therapeutic dilemma. Partial Nephrectomy may be appropriate in management of XGP in select cases. PMID: 31976820 [PubMed - as supplied by publisher]
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research
e Rha Cho Ham The molecular characteristics of early-stage clear cell renal cell carcinomas (ccRCCs) measuring ≤7 cm associated with poor clinical outcomes remain poorly understood. Here, we sought to validate genes associated with ccRCC progression and identify candidate genes to predict ccRCC aggressiveness. From among 1069 nephrectomies performed on patients, RNA sequencing was performed for 12 ccRCC patients with aggressive characteristics and matched pairs of 12 ccRCC patients without aggressive characteristics. Using a prospective cohort ( Identifier: NCT03694912), the expression...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
CONCLUSIONS: Tumor stage and its substages represent extremely important determinants of prognosis after lengthy event-free follow-up. The recorded observations have critical importance for physicians regarding patient follow-up and counseling. PMID: 31910387 [PubMed - in process]
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
We present our single centre experience in transplanted patients and future candidates for transplantation. Methods: Retrospective analysis from an anonymised database of bilateral nephrectomies for ADPKD patients. Results were reported as median, range, and percentage. Differences between groups were tested using ANOVA and t-test. Surgery was performed between January 2012 and July 2018. Results: Thirty-three patients underwent bilateral native nephrectomy for APKD. 18 had a functioning kidney transplant (transplant group, 55%) while 15 patients were on dialysis (dialysis group, 45%) at the time of surgery; 8 pa...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
CONCLUSIONS: The single-port approach has advantages as easier surgical planning and transition for combined and multi-quadrants surgeries: faster recovery, minimal postoperative pain and need for opioids, and excellent cosmetic outcome. We suggest that combined procedures should be performed only in high volume institutions by surgeons with vast experience in robotic surgery in selected patients. PMID: 31864774 [PubMed - as supplied by publisher]
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Authors: Tags: Actas Urol Esp Source Type: research
More News: African Health | Cancer | Cancer & Oncology | Carcinoma | Kidney Cancer | Nephrectomy | Sexual Abuse | Study | Urology & Nephrology | Women