Carcinome rénal à cellules chromophobes : à propos de 16 cas et une revue de la littérature

ConclusionLe cancer chromophobe du rein est une entité anatomoclinique particulière, caractérisé par un pronostic favorable grâce à un grade de Fuhrman bas et sa limitation au rein.AbstractObjectiveTo determine the histo-clinical, pathological, therapeutic and prognostic characteristics of renal chromophobe carcinomas.Subjects and methodsThis is a retrospective study including 16 cases of chromophobe carcinoma among 86 renal cancers diagnosed in the Urology Department B of Rabat University Hospital between January 2011 and August 2017.ResultsThere were 12 women and 4 men. The average age of discovery was 57.5 years. They were distributed in 62.5% predominantly eosinophilic, 37.5% of mixed tumors. The nuclei are irregular and incisured. Tumor T1 (31.5%) and T2 (56.25%) were the most common. The majority of patients had a Fuhrman grade, 43.8% grade 2 and 31.2% grade 3. Only one patient had a local recurrence. The overall 5-year survival rate was 92%. A death related to the disease has been reported. Nephrectomy is the gold standard for 100% of patients. The average overall survival rate is 34.4 months.ConclusionChromophobic kidney cancer is a particular anatomo-clinical entity, characterized by a favorable prognosis due to a low Fuhrman grade and its limitation to the kidney.
Source: African Journal of Urology - Category: Urology & Nephrology Source Type: research

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Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
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Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
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Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
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Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
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Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
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Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research
e Rha Cho Ham The molecular characteristics of early-stage clear cell renal cell carcinomas (ccRCCs) measuring ≤7 cm associated with poor clinical outcomes remain poorly understood. Here, we sought to validate genes associated with ccRCC progression and identify candidate genes to predict ccRCC aggressiveness. From among 1069 nephrectomies performed on patients, RNA sequencing was performed for 12 ccRCC patients with aggressive characteristics and matched pairs of 12 ccRCC patients without aggressive characteristics. Using a prospective cohort (ClinicalTrials.gov Identifier: NCT03694912), the expression...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
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Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Authors: Tags: Actas Urol Esp Source Type: research
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