Spectrum of movement disorders and neurotransmitter abnormalities in paediatric POLG disease

ConclusionsChildren withPOLG mutations can manifest with a wide spectrum of abnormal movements, which are often prominent features of the clinical syndrome. Underlying pathophysiology is probably multifactorial, and aberrant monoamine metabolism is likely to play a role.
Source: Journal of Inherited Metabolic Disease - Category: Internal Medicine Source Type: research