Interferon alfa-2a maintenance after salvage autologous stem cell transplantation in a mycosis fungoides patient with central nervous system involvement

Mycosis fungoides is a primary cutaneous T cell lymphoma with unfavorable prognosis for the advanced stages of the disease. Refractory disease and advanced-staged disease require systemic therapy.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research

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The immune cells of the brain are somewhat different in character and function from those of the body. They have a greater portfolio of tasks beyond chasing down pathogens, clearing out waste, and assisting in regeneration. For example, the immune cells known as microglia are involved in the maintenance of synaptic connections between neurons. Interestingly, microglia are not produced in the bone marrow by stem cells or progenitor cells, so in the research here in which young bone marrow is transplanted into old mice, one can be fairly sure that any beneficial effects on microglia result from signaling differences on the p...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Authors: Braun OÖ, Nilsson J, Gustafsson F, Dellgren G, Fiane AE, Lemström K, Hubbert L, Hellgren L, Lund LH Abstract OBJECTIVES: The purpose of this study was to assess complications and mortality and its predictors, with continuous-flow left ventricular assist devices (CF-LVADs) in the Nordic Countries. DESIGN: This was a retrospective, international, multicenter cohort study. RESULTS: Between 1993 - 2013 442 surgically implanted long-term mechanical assist devices were used among 8 centers in the Nordic countries. Of those, 238 were CF-LVADs (HVAD or HeartMate II) implanted in patients>18 ye...
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
Authors: Najjar E, Ljung Faxén U, Hage C, Donal E, Daubert JC, Linde C, Lund LH Abstract OBJECTIVES: Soluble suppression of tumorigenecity 2 (sST2) is prognostic in acute and chronic heart failure with reduced ejection fraction (HFrEF) but less studied in HF with preserved EF (HFpEF). We evaluated sST2 concentrations, correlations with biomarkers and echocardiographic measures of diastolic and systolic function, and associations with outcomes in HFpEF and HFrEF. DESIGN AND RESULTS: A total of 193 subjects from three different cohorts were included. Eighty-six HFpEF patients were obtained from the Karolin...
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
Publication date: Available online 20 February 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Jennifer Tyler, Lorie Kumer, Carolyn Fisher, Heather Casey, Hiroko ShikeAbstractChimerism testing is used to monitor engraftment and risk of relapse after allogeneic hematopoietic stem cell transplant for hematological malignancy. Although short tandem repeat (STR) method is widely used among clinical laboratories, quantitative PCR (qPCR) provides better sensitivity (0.1%) than STR (1% to 5%), but is less accurate than STR for patients in mixed chimerism. qPCR chimerism test allows evaluation of residual recipient cell...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
LUNG cancer symptoms include a cough the won ’t go away, unexplained weight loss and severe chest pain. But you could also be at risk of deadly lung tumour signs if your eyes are a distinctive colour.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
While medicine transforms cancer into a chronic disease with which patients can live for an extended period of time, financial toxicity threatens to turn chronic, too.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Health Insurance and Managed Care Drugs (Pharmaceuticals) Bankruptcies Cancer Source Type: news
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Source Type: research
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Source Type: research
Elisa Boldrin, Sandro Malacrida, Enrica Rumiato, Giorgio Battaglia, Alberto Ruol, Alberto Amadori, Daniela Saggioro
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Chin-Yap Loh, Aditya Arya, Ahmed Fadhil Naema, Won Fen Wong, Gautam Sethi, Chung Yeng Looi
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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