Molecular Design of Peptide-Fc Fusion Drugs.

Molecular Design of Peptide-Fc Fusion Drugs.
Curr Drug Metab. 2018 Aug 20;:
Authors: Ning L, He B, Zhou P, Derda R, Huang J
Abstract
Peptide-Fc fusion drugs are a category of biological therapeutics in which the Fc region of an antibody is genetically fused to a peptide of interest. In this review, we summarize the key steps in peptide-Fc fusion technology and stress the main computational resources, tools, and methods that have been used in the rational design of peptide-Fc fusion drugs. Additionally, open questions about the computer-aided molecular design of peptide-Fc are raised. Answers to these questions by future research will certainly help make the transition from peptide leads to drugs on the market quicker and cheaper.
PMID: 30129406 [PubMed - as supplied by publisher]

Source: Current Drug Metabolism - August 20, 2018 Category: Drugs & Pharmacology Authors: Ning L, He B, Zhou P, Derda R, Huang J Tags: Curr Drug Metab Source Type: research