The importance of the structure similarity of drugs used for depression and inflammation, two comorbid diseases.

The importance of the structure similarity of drugs used for depression and inflammation, two comorbid diseases. Curr Top Med Chem. 2018 Aug 21;: Authors: Bayram FEO, Reis R, Tuncer B, Sipahi H Abstract Growing evidence links inflammation to depression and the combination of anti-inflammatory drugs with antidepressant to treat depressive symptoms is currently suggested. There is only few studies concerning the molecular mechanism underlying this comorbidity and many of them point out the importance of the tryptophan pathway. There is yet no data that analyzes the structural similarity of the molecules used for the treatment of these comorbid diseases. This review aimed first to classify current antidepressant drugs and non-steroidal anti-inflammatory drugs (NSAIDs) according to their structure. Molecules with two aromatic rings linked with a heteroatom or a carbonyl group (vortioxetine, ketoprofen, diclofenac), or presenting a naphtyl moiety in their structure (duloxetine, agomelatine, naproxen, nabumetone) were found to be structurally related. The antidepressant activity of these NSAIDs and the anti-inflammatory activity of these antidepressants were investigated. The literature search interestingly revealed reports indicating a serotonin-related antidepressant activity of the NSAIDs for structures found to be structurally similar to some antidepressants. Similarly, the anti-inflammatory activity of the corresponding antidepressant...
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research