Dengue seroprevalence and its socioeconomic determinants in Faisalabad, Pakistan: a cross-sectional study

CONCLUSIONS: An integrated approach is required to control the menace through vector control strategies and improvement of socioeconomic conditions.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research

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Publication date: 16 November 2019Source: New Scientist, Volume 244, Issue 3256Author(s): Sam WongA vaccine based on a weakened version of the dengue virus was 80 per cent effective at preventing infections after one year in a trial of 20,000 children
Source: New Scientist - Category: Science Source Type: research
A new lignanamide derivative, lycichinenamide (1), has been isolated from the root barks ofLycium chinense together with nine known compounds, lyciumamide H (2), 5,2 ′-dihydroxy-6,7,8,6′-tetramethoxyflavone (3), 7α,8β-3 ′-O-methylcedrusin (4), smiglabrol (5),trans-N-caffeoyltyramine (6), vanillic acid (7), syringic acid (8), 2,6-dimethoxy-1,4-benzoquinone (9), and 1,5-dihydroxy-2-isoprenyl-3-methoxyxanthone (10). The structure of the new compound1 was determined through spectroscopic and MS analyses. Among the isolates, lycichinenamide (1), lyciumamide H (2), smiglabrol (5), andtrans-N-caffeoyl...
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research
Publication date: Available online 14 November 2019Source: Biosensors and BioelectronicsAuthor(s): Pandiyaraj Kanagavalli, Murugan VeerapandianAbstractTransforming the structural and functional properties of carbon nanostructures are highly beneficial for healthcare diagnostics. This research demonstrates the functionalization of opto-electrochemically active ruthenium bipyridine complex (Ru(II)) on the surface of graphene oxide (GO), enabling a dual-functional immunoprobe for the detection of non-structural 1 (NS1) protein, a dengue biomarker. Structural investigations reveals that Ru(II) has intermolecular bonding with f...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
(Ecole Polytechnique F é d é rale de Lausanne) A new EPFL and MIT study into the interplay between mobility and the 2013 and 2014 dengue outbreaks in Singapore has uncovered a legal void around access to mobile phone data -- information that can prove vital in preventing the spread of infectious diseases.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
CONCLUSIONS: The results appear to demonstrate an imbalance between vascular endothelial permeability regulating events in renal lesions in SD. The increase in the expression of ICAM-1 and VCAM-1 is an in-situ indicator of higher permeability with a consequent influx of cells favoring the inflammation of the endothelium. These molecules are important in the pathophysiology of the disease and provide the possibility of developing new markers for the evaluation, clinical follow-up, and therapeutic response of patients with SD.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
Lu Lu Recently, Zika virus (ZIKV) has attracted much attention in consideration of its association with severe neurological complications including fetal microcephaly. However, there are currently no prophylactic vaccines or therapeutic drugs approved for clinical treatments of ZIKV infection. To determine the potential anti-ZIKV inhibitors, we screened a library of clinical drugs with good safety profiles. Erythromycin estolate (Ery-Est), one of the macrolide antibiotics, was found to effectively inhibit ZIKV infection in different cell types and significantly protect A129 mice from ZIKV-associated neurological sign...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
The objective of this study was to evaluate the anti-ZIKV IgG prevalence in blood donors from the Northeast region of the S ão Paulo State, Brazil, which experienced a ZIKV outbreak in 2016.
Source: Journal of Infection - Category: Infectious Diseases Authors: Tags: RESEARCH ARTICLE Source Type: research
Abstract Dengue fever is an acute infectious disease caused by dengue virus (DENV) and transmitted by Aedes mosquitoes. There is no effective vaccine or antiviral drug available to date to prevent or treat dengue disease. Recently, RNA-dependent RNA polymerase (RdRp), a class of polymerases involved in the synthesis of complementary RNA strands using single-stranded RNA, has been proposed as a promising drug target. Hence, we screened new molecules against DENV RdRp using our previously constructed virtual screening method. Mol-5, [1,2,4]triazolo[1,5-a]pyrimidine derivative, was screened out from an antiviral comp...
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharmacol Sin Source Type: research
by Nur Alia Johari, Kenny Voon, Shen Yung Toh, Lokman Hakim Sulaiman, Ivan Kok Seng Yap, Patricia Kim Chooi Lim Dengue fever is endemic in Malaysia, contributing to significant economic and health burden in the country.Aedes aegypti andAe.albopictus are the main vectors of the dengue virus (DENV), which circulates in sylvatic and human transmission cycles and has been present in Malaysia for decades. The study investigated the presence and distribution of DENV in urban localities in the Klang Valley, Peninsular Malaysia. A total of 364Ae.aegypti and 1,025Ae.albopictus larvae, and 10Ae.aegypti and 42Ae.albopictus adult mos...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
ABSTRACTAedes aegyptiandAedes albopictusare invasive mosquito species with geographic ranges that have oscillated within Florida since their presence was first documented. Local transmission of dengue, chikungunya, and Zika viruses serves as evidence of the public health importance of these two species. It is important to have detailed knowledge of their distribution to aid in mosquito control efforts and understand the risk of arbovirus transmission to humans. Through a partnership involving the University of Florida Institute of Food and Agricultural Sciences Cooperative Extension Service and the Florida Medical Entomolo...
Source: Journal of Vector Ecology - Category: Biology Authors: Tags: Original Article Source Type: research
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