Response to Association of Prolonged QTc Interval With Takotsubo Cardiomyopathy: A Neurocardiac Syndrome Inside the Mystery of the Insula of Reil

Clinical Cardiology,Volume 0, Issue ja, -Not available-.
Source: Clinical Cardiology - Category: Cardiology Authors: Source Type: research

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AbstractAs the price of next-generation sequencing keeps decreasing, cost is becoming a less important discriminator for diagnostic laboratories in choosing the preferred type of approach to genetic testing. Genome-wide sequencing strategies will plausibly become the standard first-tier tools for genetic testing, with the potential for deeper understanding of the genetic architecture of cardiomyopathies and discovery of the underlying aetiology in the many patients in whom the genetic cause remains elusive. Routine usage of extended sequencing assays will also enable “genetic-first diagnostics”, particularly fo...
Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
Ronnie and colleagues reported a case of a 10-year-old female with a history of systemic lupus erythematosus (SLE) complicated by hypertension and cardiomyopathy secondary to lupus who presented to the emergency department with a history of vision loss and headache [1]. The authors diagnosed the patient with posterior reversible encephalopathy syndrome (PRES). Although interesting, the diagnostic criteria for PRES was not met.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
In this study, to investigate the mechanisms of PER in cardiac protection, a rat model of cardiomyopathy was established by continuous isoproterenol (ISO) stimulation. Changes in the body weight, heart weight index, echocardiography, histological staining, mitochondrial microstructure, and biochemical indicators were examined. Our results demonstrate that PER reduced myocardial remodeling, inhibited deterioration of cardiac function, and delayed HF onset in rats with ISO-induced cardiomyopathy. PER markedly reduced reactive oxygen species (ROS) production, increased the levels of antioxidant enzymes, inhibited mitochondria...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 19 February 2020Source: Arab Journal of GastroenterologyAuthor(s): Mehmet Baysal, Yıldız Ortaburun, Ali Rıza Soylu, Mustafa Adem Yılmaztepe, Serap Baysal, Elif Umit, Hasan Umit, Ahmet Tezel, Ahmet Muzaffer DemirAbstractBackground and study aimsCirrhosis is a multisystem disorder characterized by hyperdynamic circulation which can progress to multiple organ dysfunctions. Recent studies have demonstrated autonomic dysfunction and cirrhotic cardiomyopathy including diastolic dysfunction, systolic dysfunction with electrophysiologic abnormalities in patients with cirrhosis. Due to the lon...
Source: Arab Journal of Gastroenterology - Category: Gastroenterology Source Type: research
AbstractBackgroundImplantable cardioverter-defibrillators (ICDs) are designed to deliver therapy in the event of malignant ventricular arrhythmias. Despite their benefits, some ICD recipients regret their decision on device implantation.ObjectivesThe aim of this study was to evaluate the incidence, predictors, and consequences of recipients that regretted their decision after implantation.MethodsA questionnaire-based cross-sectional survey of consecutive ICD recipients examined during a  routine outpatient follow-up visit was conducted. Their level of depression and anxiety was assessed with the hospital anxiety and d...
Source: Herzschrittmachertherapie und Elektrophysiologie - Category: Cardiology Source Type: research
CONCLUSION:  The results indicate that the methods applied would be efficient for the identification of these genetic cardiac diseases. PMID: 32079026 [PubMed - as supplied by publisher]
Source: Methods of Information in Medicine - Category: Information Technology Authors: Tags: Methods Inf Med Source Type: research
An 18 y.o. female who presented for chest pain. Patient reports productive cough and headache x 4 days. She notes persistent sternal chest pain worse at night and waking her from sleep. She also notes intermittent abdominal pain, describing as a " tightness " ." Sinus arrhythmia with variable right bundle origin PVCs "Is this accurate?No.This is sinus bradycardia with a slightly accelerated right ventricular escape, such that sometimes:1.  the sinus beat is conducted before any ventricular escape (beats 7)2.  the ventricular beat starts at almost the exact same time as the P-wave, and the P-wa...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
This study aimed to determine the time course of development of diabetic cardiomyopathy in a model of type 1 diabetes (T1D) in vivo. Diabetes was induced in 6-week-old male FVB/N mice via streptozotocin (55 mg/kg i.p. for 5 days; controls received citrate vehicle). At 2, 4, 8, 12, and 16 weeks of untreated diabetes, left ventricular (LV) function was assessed by echocardiography before post-mortem quantification of markers of LV cardiomyocyte hypertrophy, collagen deposition, DNA fragmentation, and changes in components of the hexosamine biosynthesis pathway (HBP) were assessed. Blood glucose and HbA1c levels were elevated...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Nature Reviews Cardiology, Published online: 20 February 2020; doi:10.1038/s41569-020-0339-2Diabetic cardiomyopathy occurs as a result of the dysregulated glucose and lipid metabolism, increased oxidative stress and activation of pro-inflammatory pathways associated with diabetes mellitus, which can induce cardiac remodelling and dysfunction. In this Review, Tan and colleagues discuss the pathogenesis of diabetic cardiomyopathy and describe signalling pathways that might be potential therapeutic targets.
Source: Nature Reviews Cardiology - Category: Cardiology Authors: Source Type: research
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