FKBP5 polymorphisms and hypothalamic-pituitary-adrenal axis negative feedback in major depression and obsessive-compulsive disorder

Publication date: Available online 9 August 2018Source: Journal of Psychiatric ResearchAuthor(s): Alex Ferrer, Javier Costas, Javier Labad, Neus Salvat-Pujol, Cinto Segalàs, Mikel Urretavizcaya, Eva Real, Aida de Arriba-Arnau, Pino Alonso, José M. Crespo, Marta Barrachina, Carles Soriano-Mas, Ángel Carracedo, José M. Menchón, Virginia SoriaAbstractMajor depressive disorder (MDD) and obsessive-compulsive disorder (OCD) have both been linked to abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis. Polymorphisms in the genes involved in HPA axis activity, such as FKBP5, and their interactions with childhood trauma have been associated with stress-related mental disorders. Our goal was to study the role of FKBP5 genetic variants in HPA axis negative feedback regulation as a possible risk factor for different mental disorders such as MDD and OCD, while controlling for childhood trauma, anxiety and depressive symptoms. The sample included 266 participants divided into three groups: 1) MDD (n = 89 [n = 73 melancholic; n = 3 atypical]), 2) OCD (n = 51; 39% with comorbid MDD [n = 13 melancholic; n = 7 atypical]) and 3) healthy controls (n = 126). Childhood trauma, trait anxiety and depressive symptoms were assessed. HPA negative feedback was analyzed using the dexamethasone suppression test ratio (DSTR) after administration of 0.25 mg of dexamethasone. Eleven SNPs in the FKBP5 gene were selected for genotyping. Multiple linear regressions, ...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research