The correlation of NLRC3 expression to the progression and prognosis of hepatocellular carcinoma
NLRC3 is a member of the NLR (nucleotide-binding domain and leucine-rich repeat) family protein that plays a role in inflammation and immunity. Although chronic inflammation has been identified as a hallmark of cancer, whether NLRC3 expression correlated to the development and prognosis of hepatocellular carcinoma (HCC) is unclear. In the present study, we first used Oncomine and OncoLnc database to determine the clinical significance of NLRC3 in HCC. Then we performed quantitative real-time polymerase chain reaction (qRT-PCR), western-blot and immunohistochemical staining (IHC), and analyzed the correlation between NLRC3 expression and clinicopathological features in HCC of Chinese population.
Source: Human Pathology - Category: Pathology Authors: Ying-Yu Ma, Guo-Hai Zhang, Jingjing Li, Shi-Bing Wang, Zhi-Ming Hu, Cheng-Wu Zhang, Erguang Li Tags: Original contribution Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | China Health | Databases & Libraries | Hepatocellular Carcinoma | Liver Cancer | Pathology | Study