Early life seizures: Evidence for chronic deficits linked to autism and intellectual disability across species and models.

Early life seizures: Evidence for chronic deficits linked to autism and intellectual disability across species and models.
Exp Neurol. 2014 Oct 2;
Authors: Bernard PB, Benke TA
Abstract
Recent work in Exp Neurol by Lugo et al. (2014b) demonstrated chronic alterations in sociability, learning and memory following multiple early life seizures (ELSs) in a mouse model. This work adds to the growing body of evidence supporting the detrimental nature of ELSs on the developing brain to contribute to aspects of an autistic phenotype with intellectual disability. Review of the face validity of behavioral testing and the construct validity of the models used informs the predictive ability and thus the utility of these models to translate underlying molecular and cellular mechanisms into future human studies.
PMID: 25284323 [PubMed - as supplied by publisher]

Source: Experimental Neurology - October 2, 2014 Category: Neurology Authors: Bernard PB, Benke TA Tags: Exp Neurol Source Type: research