The release of perillyl alcohol from the different kind of vehicles.

The release of perillyl alcohol from the different kind of vehicles.
Curr Pharm Biotechnol. 2018 Jul 30;:
Authors: Miastkowska M, Konieczna M, Lason E, Tabaszewska M, Sikora E, Ogonowski J
Abstract
BACKGROUND: Skin cancers are the most common malignancy of humans, and the number of cases has increased dramatically in the past few decades. Therefore, it is very important to carry out studies concerning new and safer anticancer natural agents (e.g. perillyl alcohol) and modern drug delivery systems, such as nanoformulations, which increase their bioavailability.
OBJECTIVES: The aim of this work was to obtain different kinds of topical vehicles formulation and compare their efficiency in the release of perillyl alcohol. The release kinetics was determined by using certain selected mathematical models.
METHOD: Formulations of a hydrogel, O/W nanoemulsion, O/W macroemulsion and nanostructured lipid carrier were developed as carriers for perillyl alcohol - one of the promising anticancer natural agents. The release study of the active was carried out using the Spectra/Por Standard Regenerated Cellulose membrane, at temperature T=320C. The concentration of active agents in the receptor solution was analyzed by high performance liquid chromatography. The release kinetics was determined by using selected mathematical models.
RESULTS: The results of our release studies have shown that the highest and comparable amount o...

Source: Current Pharmaceutical Biotechnology - July 30, 2018 Category: Biotechnology Authors: Miastkowska M, Konieczna M, Lason E, Tabaszewska M, Sikora E, Ogonowski J Tags: Curr Pharm Biotechnol Source Type: research