Optimization of Linalool-loaded Solid Lipid Nanoparticles using Experimental Factorial Design and Long-term Stability Studies with a New Centrifugal Sedimentation Method

Publication date: Available online 31 July 2018Source: International Journal of PharmaceuticsAuthor(s): Irina Pereira, Zielińska, Nuno R. Ferreira, Amélia M. Silva, Eliana B. SoutoAbstractLinalool (C10H18O), also known as 3, 7-dimethyl-1, 6-octadien-3-ol, is the most common acyclic monoterpene tertiary alcohol present in essential oils of several aromatic plant species. Previous studies indicate that linalool is a valuable compound with a wide range of therapeutic properties. The promising therapeutic effects of linalool are however limited by its poor water solubility and volatility. Recently, the encapsulation of linalool in drug delivery systems, such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) has demonstrated to overcome linalool physicochemical limitations. The present study aimed the production and optimization of linalool encapsulation in SLN applying the experimental full factorial design. The estimation of the long-term stability of the produced linalool-loaded SLN was carried out using a new centrifugal sedimentation method, LUMiSizer®. SLN dispersions were produced by the hot high pressure homogenization (HPH) method. The influence of the independent variables, surfactant and lipid concentrations on linalool-loaded SLN particle size, polydispersity index (PI) and zeta potential (ZP) was evaluated by a 22 factorial design composed of 2 variables which were set at 2-levels each. For each of the three dependent variables, analysis of...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research