Disease trajectories in behavioural variant frontotemporal dementia, primary psychiatric and other neurodegenerative disorders presenting with behavioural change

Publication date: Available online 1 August 2018Source: Journal of Psychiatric ResearchAuthor(s): Lianne M. Reus, Everard GB. Vijverberg, Betty M. Tijms, Mara ten Kate, Flora Gossink, Welmoed A. Krudop, Marta del Campo, Charlotte E. Teunissen, Frederik Barkhof, Wiesje M. van der Flier, Pieter Jelle Visser, Annemiek Dols, Yolande AL. PijnenburgAbstractBehavioural variant frontotemporal dementia (bvFTD) is characterized by behavioural and social cognitive disturbances, while various psychiatric and neurodegenerative disorders may have similar clinical symptoms. Since neurodegenerative disorders are eventually progressive, whereas primary psychiatric disorders are not, this study aimed to investigate whether the change in clinical symptoms over time differed between groups and which biomarkers predicted rate of decline.Disease trajectories (median follow-up = 3 years) of frontal and stereotyped behaviour, general and frontal cognitive functioning, and social cognition were examined in bvFTD (n = 34), other neurodegenerative (n = 28) and primary psychiatric disorders (n = 43), all presenting with late-onset frontal lobe syndrome (45–75 years), using linear mixed models. To gain more insight in underlying pathological processes driving disease progression, we studied the association of baseline cerebrospinal fluid (CSF) (neurofilament light (NfL) and YKL-40 levels, phosphotau181 to total tau ratio) and neuroimaging markers with disease trajectories.Frontal behavi...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research