Effects of acute olanzapine exposure on central insulin-mediated regulation of whole body fuel selection and feeding

The use of antipsychotics (APs) is increasing at an alarming rate, owing to expanding on- and off-label uses in adults and children (Pringsheim and Gardner, 2014). This is concerning due to the severe metabolic side effects associated with chronic and acute AP-use. In addition to the increased propensity for weight gain and related comorbidities (Bergman and Ader, 2005), acute AP-exposure is associated with rapid, unmatched fuel repartitioning (Klingerman et al., 2014). Specifically, treatment with the AP olanzapine has been shown to increase hepatic glucose output (Houseknecht et al., 2007) and decrease adipose tissue lipolysis, while simultaneously promoting reliance on fat oxidation (as demonstrated by reduced respiratory exchange ratio [RER]) for energy requirements (Klingerman et al., 2014).

Source: Psychoneuroendocrinology - July 30, 2018 Category: Psychiatry Authors: Laura N. Castellani, Jennifer Wilken, Andrew Abela, Louise Benarroch, Zohra Ahasan, Celine Teo, Virginia Wilson, Chantel Kowalchuk, Adria Giacca, Gary J. Remington, Margaret K. Hahn Tags: Short Communication Source Type: research