Latency to startle is reduced in the 5xFAD mouse model of Alzheimer's disease.

Latency to startle is reduced in the 5xFAD mouse model of Alzheimer's disease. Behav Brain Res. 2018 Jul 25;: Authors: Story D, Chan E, Munro N, Rossignol J, Dunbar GL Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder that results in cognitive decline and a number of other neuropsychiatric symptoms. One area that is often affected by neuropsychiatric disease is the response to sudden, loud noises, as measured by the acoustic startle response (ASR), and prepulse inhibition (PPI), which indicates sensory-gating abilities. Evidence suggests AD patients, even early in the disease, show alteration in ASR. Studies have also shown changes in this measure in transgenic mouse models of AD. To assess the homology of 5xFAD mice to AD patients, the current study analyzed several aspects of the startle response in these mice using a protocol with fewer trials than previous studies. It was found that the 5xFAD mice had a delayed startle response, similar to what has been observed in AD sufferers. These results suggest the ASR may be a useful tool in assessing the efficacy of potential therapeutics, and that a simplified protocol may be more sensitive to between-groups differences for this task. PMID: 30055208 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

Related Links:

A proof-of-concept study shows regular aerobic exercise may prevent or slow cognitive decline in older adults at risk for Alzheimer's.
Source: - Health - Category: Consumer Health News Source Type: news
This study brings us one step closer toward teasing out the effects in people with biomarker defined Alzheimer’s.” While the study results must be replicated in much larger studies, Zhang suggested that anyone concerned about cognitive decline or Alzheimer’s consider adding exercise to their daily lives. While it’s best to start exercising early in life, he said, “it is not too late to receive the benefits of exercise even late in life when there are already amyloid clumps in the brain.” The-CNN-Wire &© 2019 Cable News Network, Inc., a Time Warner Company. All rights reserved.
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Syndicated CBSN Boston Alzheimer's Disease CNN Source Type: news
Authors: Randolph C Abstract Correctly diagnosing early symptomatic Alzheimer disease in the context of multinational clinical trials poses a significant challenge. Subjective complaints of memory are fairly ubiquitous in an older population, and establishing the presence of definitive cognitive decline from clinical assessments is difficult. Most such trials have adopted the use of standardized episodic memory measures as an inclusion criterion, typically setting the cutoff at one standard deviation below age normal means. This is useful in terms of establishing the presence of an objective impairment of memory, t...
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
Chalcones are compounds with wide interesting biological activities including Alzheimer ’ s disease. A comparative study was performed between the chalcones (E)-1-(2-aminophenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one and 1-(6-amino-1,3-benzodioxol-5-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one regarding the influence of benzodioxol group on their molecular conformations. The first chalcone was neutralized with dilute hydrochloric acid, while solid of the second was filtered and recrystallized from ethanol, both on centrosymmetric space group P21/c. Their molecular packing were evaluated by Hirshfeld surfaces, an...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
Alzheimer’s disease (AD) is the most common type of dementia worldwide. The deposition of amyloid β (Aβ) is one of the most important pathological changes in AD. Autophagy, which mediates degradation of toxic proteins and maintains normal neuronal function, is dysfunctional in AD; dysfunctional autophagy is believed to be a critical pathological feature of AD. Here, we evaluated the in vitro and in vivo effects of a traditional Chinese medicinal formula called Yizhiqingxin formula (YQF) on autophagy. We determined that treatment with a high dose of YQF improved spatial memory and decreased the hippocampal A...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
We describe how careful data unification, time-alignment, and imputation techniques can handle missing data rates inherent in real-world settings and ultimately show utility of these disparate data in differentiating symptomatics from healthy controls based on features computed purely from device data. The Study in Context: The FDA creates new Digital Health unit to reimagine regulatory paths in the age of scalable, AI-enhanced innovation Five reasons the future of brain enhancement is digital, pervasive and (hopefully) bright Mindstrong Health identifies digital biomarkers of cognitive function using smartphone data Neu...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology Alzheimers-disease Apple behavioral cognitive decline dementia Eli Lilly Evidation healthcare HIPAA mental-decline mild-cognitive-impairment physiological Source Type: blogs
The widely expected move comes months after the companies scrapped trials of another Alzheimer ’s drug.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
Here Matthew O'Connor of the SENS Research Foundation talks about the research that led to founding of Underdog Pharmaceuticals, a biotech startup incubated by the foundation to commercialize a means of targeting 7-ketocholesterol in atherosclerosis and other conditions. Oxidized cholesterols, and largely 7-ketocholesterol, are the primary cause of dysfunction in the macrophage cells normally responsible for preventing the build up of fatty plaques in blood vessel walls. That dysfunction is the cause of atherosclerosis, and the fact that the presence of oxidized cholesterols increases with age is one of the reasons why ath...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
Donepezil, a common Alzheimer's disease drug, is linked to a two-fold higher risk of hospital admission than other cholinesterase inhibitors, a Canadian medical study found Monday.
Source: Health News - - Category: Consumer Health News Source Type: news
The Federal Trade Commission sent warning letters to three companies that sell oils, tinctures, capsules, “gummies,” and creams containing cannabidiol (CBD), a chemical compound derived from the cannabis plant.
Source: NCCAM Featured Content - Category: Complementary Medicine Authors: Source Type: news
More News: Alzheimer's | Brain | Neurology | Study