Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI.

In conclusion, the present study is in agreement with the concept that pericentral CYPs form NAPQI that in the same cell binds to and depletes GSH but a lower level of GSH adducts is also observed in the periportal region. The results also provide further evidence of the recently published concept of 'aggravated loss of clearance capacity' according to which also liver tissue that survives intoxication may transiently show decreased metabolic capacity. PMID: 30039229 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30039229?dopt=Abstract

Source: Archives of Toxicology - July 23, 2018 Category: Toxicology Authors: Sezgin S, Hassan R, Zühlke S, Kuepfer L, Hengstler JG, Spiteller M, Ghallab A Tags: Arch Toxicol Source Type: research