Pioglitazone reduces lipid droplets in cholesterolosis of the gallbladder by increasing ABCA1 and NCEH1 expression.

In conclusion, we observed that pioglitazone increased ABCA1 expression in an LXR-dependent manner and NCEH1 expression in an LXRα-independent manner, which mobilized CE hydrolysis and cholesterol efflux to reduce lipid droplet content in cholesterolosis GBECs. Our data provide a plausible alternative to human gallbladder cholesterolosis. PMID: 25280398 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/25280398?dopt=Abstract

Source: Molecular and Cellular Biochemistry - October 4, 2014 Category: Biochemistry Authors: Wang JM, Wang D, Tan YY, Zhao G, Ji ZL Tags: Mol Cell Biochem Source Type: research