Interleukin-6 trans-signaling and pathological low back pain in patients with Paget disease of bone

The interleukin (IL)-6 biological system plays a key role in the pathogenesis of Paget disease (PD) of bone and pathological bone pain. Bone pain, particularly in the lower back region, is the most frequent symptom in patients with PD. This case–control study aimed to evaluate the relationship between the IL-6 system and low back pain (LBP) in patients with PD. We evaluated 85 patients with PD, with the disease localized in the lumbar spine, pelvis, and/or sacrum, and classified them based on the presence or absence of LBP, before and after aminobisphosphonate treatment. We also examined 32 healthy controls without LBP. Before treatment, IL-6 levels in patients with PD were higher than those in the controls, without difference between patients with or without LBP. Patients with PD with LBP (35/85) showed higher IL-6-soluble receptor (sIL-6R) and lower soluble glycoprotein (sgp) 130 levels compared with both patients with PD without LBP and controls (sIL-6R: 46.9 ± 7.4 vs 35.4 ± 8.6 vs 29.9 ± 4.2 ng/mL; sgp130: 307.2 ± 35.4 vs 341.4 ± 41.4 vs 417.1 ± 58.5 ng/mL, respectively). Paget disease remission, 6 months after treatment, is associated with LBP improvement. This phenomenon is associated with reduced sIL-6R levels and increased sgp130 levels in patients with PD with LBP at the baseline. Considering the biological properties of IL-6, sIL-6R, and sgp130, the results of the study suggest that the perception of LBP in patients wi...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research

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Publication date: November 2019Source: International Journal of Industrial Ergonomics, Volume 74Author(s): Trond Kongsvik, Øyvind Dahl, Ingunn Marie Holmen, Trine ThorvaldsenAbstractFew studies have explored the potential connection between safety climate and health issues. However, some recent research findings indicate that a poor safety climate can be considered a stressor that may be associated with physical symptoms and musculoskeletal complaints. This link is further explored in the present study on the basis of a questionnaire study of 446 sharp-end workers in the Norwegian aquaculture industry. The analysis ...
Source: International Journal of Industrial Ergonomics - Category: Occupational Health Source Type: research
Conclusions Surgical repair with muscle flap coverage, with or without ligation of profunda femoris artery, does not affect prognosis. An alternative method for identifying healthy segments of femoral artery may be frozen section and examination of the artery to decrease the risk of recurrence at the site of anastomosis.RESUMO Contexto A doen ça de Behçet (DB) é uma enfermidade autoimune que envolve múltiplos sistemas. A manifestação arterial mais comum em pacientes com DB é o pseudoaneurisma, que tem uma frequência mais alta do que a formação de aneurism...
Source: Jornal Vascular Brasileiro - Category: Surgery Source Type: research
Resumo A s índrome da congestão pélvica (SCP) é definida como dor pélvica crônica há mais de 6 meses associada a varizes perineais ou vulvares, resultantes do refluxo ou obstrução das veias gonadais, glúteas ou periuterinas. A SCP é responsável por 16-31% dos casos de dor pélvica crônica, sendo d iagnosticada sobretudo na terceira e quarta décadas de vida. Nos últimos anos, houve um interesse maior nessa patologia por parte dos cirurgiões vasculares devido à sua associação com insufici&e...
Source: Jornal Vascular Brasileiro - Category: Surgery Source Type: research
Introduction Exercise therapy (ET) is advocated as a treatment for chronic nonspecific low back pain (CNSLBP). However, therapy effect sizes remain low. In other chronic disorders, training at higher intensity has resulted in greater improvements on both general health related and disease specific outcomes compared to lower-intensity ET. Possibly, high-intensity training also improves effect sizes in CNSLBP. Objective To compare the effects of a high-intensity ET program with a similar moderate-intensity ET program on disability, pain, function, exercise capacity, and abdominal/back muscle strength in persons with CNS...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
When surgeons cut their prescribing of opioids for pain by more than 50%, their patient-satisfaction scores didn't suffer, a small U.S. study found.Reuters Health Information
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Anesthesiology News Source Type: news
AbstractThe aim of the study was to compare CE-MRV with DANTE-SPACE on a 1.5T MRI system for the diagnosis of DVT. The patients were diagnosed with deep venous thrombosis of the lower extremities based on swelling, pain, and superficial varicose veins of the lower extremities. MRI examination confirmed the diagnosis. DANTE-SPACE images were obtained before the conventional contrast-enhanced MRV, which uses gadolinium. The scanning field started from the end of the inferior vena cava to the end of the ankle, divided into five observation segments, namely, the common iliac vein, external iliac vein, femoral vein, popliteal v...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
DISCUSSION: Patient-reported pain at hospital discharge was associated with increased narcotic use in the 90-day postoperative period. PMID: 31714420 [PubMed - as supplied by publisher]
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
The objective of this study was to describe the main diseases that can present with this radiologic sign, such as Hodgkin lymphoma, Paget's disease, metastatic prostate cancer, breast cancer, and osteomyelitis. It is extremely important that radiologists be aware of this finding in order to inform the requesting physician of the possible etiologies, given that it can be the initial radiologic presentation for these diseases.Resumo Pacientes com dor lombar são frequentemente atendidos em todos os níveis de saúde. O início da investigação diagnóstica, de modo geral, se d&aacut...
Source: Radiologia Brasileira - Category: Radiology Source Type: research
A 51-year-old man presented with low back pain. Lumbar spine plain radiographs showed loss of height in the L1 and L2 vertebral bodies with retropulsion, but expansion in transverse and anterior-posterior dimensions, and sclerosis (Fig. 1). T1- and T2-weighted magnetic resonance images demonstrated low signal intensity in L1 and L2 vertebrae, with some preserved intramedullary fat. Severe spinal stenosis and conus medullaris compression were also noted. No soft tissue component was identified. Postcontrast imaging revealed heterogeneous enhancement at L1 and L2, with the intervertebral disc spaces spared (Figs. 2 and 3).
Source: The Spine Journal - Category: Orthopaedics Authors: Tags: Images of Spine Care Source Type: research
A 51-year-old man presented with low back pain. Lumbar spine plain radiographs showed loss of height in the L1 and L2 vertebral bodies with retropulsion, but expansion in transverse and anterior-posterior dimensions, and sclerosis (Fig. 1). T1 and T2 -weighted MR images demonstrated low signal intensity in these vertebrae with some preserved intramedullary fat. Severe spinal stenosis and conus medullaris compression were also noted. No soft tissue component was identified. Postcontrast imaging revealed heterogeneous enhancement at L1 and L2, sparing intervertebral disc spaces (Figs.
Source: The Spine Journal - Category: Orthopaedics Authors: Tags: Images of Spine Care Source Type: research
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