Cognitive impairment in a rat model of neuropathic pain: role of hippocampal microtubule stability

We report here that rats exhibited memory deficits after spared nerve injury (SNI). We found that levels of stable microtubule (MT) were increased in the hippocampus of the rats with memory deficits. This increase in stable MT is marked by α-tubulin hyperacetylation. Paclitaxel, a pharmacological MT stabilizer, increased the level of stable MT in the hippocampus and induced learning and memory deficits in normal rats. Furthermore, paclitaxel reduced long-term potentiation in hippocampal slices and increased stable MT (evidenced by α-tubulin hyperacetylation) levels in hippocampal neuronal cells. Intracerebroventricular infusion of nocodazole, an MT destabilizer, ameliorated memory deficits in rats with SNI-induced nociceptive behavior. Expression of HDAC6, an α-tubulin deacetylase, was reduced in the hippocampus in rats with cognitive impairment. These findings indicate that peripheral nerve injury (eg, SNI) affects the MT dynamic equilibrium, which is critical to neuronal structure and synaptic plasticity.
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research

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ConclusionThe incidence rate of peroneal tendon subluxation is relatively low, and surgery is the primary treatment of this type of injury, with various available surgical methods available for the performing surgeon. Peroneal groove deepening and retinaculum ligament repair offers a satisfactory outcome.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Conclusions: EA treatment can decrease the expression of hypothalamic CRF and CRF-R1, relieve anxiety and depression, meanwhile reduce the expression of CRF-R1 in the gastrointestinal mucosa, increase ZO-1 expression, and adjust tight junctions (TJs) to repair the intestinal mucosal barrier. The above roles suggest that EA may play a dual role in alleviating the gastrointestinal and psychological symptoms of IBS, suggesting a potentially dual therapeutic role for EA in regulating disorders of gut-brain interaction in IBS rats. PMID: 31737064 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Authors: Fukuda H, Takekuma M, Hirashima Y Abstract A 62-year-old Japanese woman developed numbness of the extremities and megaloblastic anemia. She had undergone total abdominal hysterectomy, whole-pelvis radiation therapy and chemotherapy for gynecological cancer 10 years before. Chronic abdominal pain, diarrhea and intermittent small-bowel obstruction had afflicted her for a long time. We diagnosed her with vitamin B12 deficiency anemia and polyneuropathy due to chronic radiation enteritis causing malabsorption. Vitamin B12 injections improved her numbness and anemia. The early diagnosis and treatment of deficie...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
The Pharmacogenomics Journal, Published online: 20 November 2019; doi:10.1038/s41397-019-0118-9Gender based differences, pharmacogenetics and adverse events in chronic pain management
Source: The Pharmacogenomics Journal - Category: Drugs & Pharmacology Authors: Source Type: research
A new study from the British Columbia Centre on Substance Use has found that daily cannabis users were 50% less likely to use illicit opioids, such as heroin, to manage their chronic pain.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conditions:   Knee Osteoarthritis;   Pain, Chronic Intervention:   Procedure: Acupuncture Sponsor:   University of Sao Paulo General Hospital Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Chronic Low Back Pain Intervention:   Other: Health-Related Quality of Life Report Sponsor:   University of North Texas Health Science Center Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Pain, Chronic;   Sympathetic Disorder;   Ultrasound Therapy Intervention:   Device: ultrasound and CT Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Knee Osteoarthritis;   Pain, Chronic Intervention:   Procedure: Acupuncture Sponsor:   University of Sao Paulo General Hospital Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Chronic Low Back Pain Intervention:   Other: Health-Related Quality of Life Report Sponsor:   University of North Texas Health Science Center Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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