Quantitation of NAD+: Why do we need to measure it?

Publication date: Available online 23 July 2018Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Yue Liu, James Clement, Ross Grant, Perminder Sachdev, Nady BraidyAbstractBackgroundNicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that is currently investigated as an important target to extend lifespan and health span. Age-related NAD+ depletion due to the accumulation of oxidative stress is associated with reduced energy production, impaired DNA repair and genomic instability.Scope of reviewNAD+ levels can be elevated therapeutically using NAD+ precursors or through lifestyle modifications including exercise and caloric restriction. However, high amounts of NAD+ may be detrimental in cancer progression and may have deleterious immunogenic roles.Major conclusionsStandardized quantitation of NAD+ and related metabolites may therefore represent an important component of NAD+ therapy.General significanceQuantitation of NAD+ may serve dual roles not only as an ageing biomarker, but also as a diagnostic tool for the prevention of malignant disorders.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research