Deciphering the Far-Reaching Functions of Non-coding RNA in Colorectal Cancer
AbstractPurpose of ReviewColorectal cancer (CRC) is one of the deadliest forms of cancer worldwide, and researchers are continuously striving to discover novel therapeutic targets and treatment methods. Many of the molecular mechanisms central to CRC development and progression have yet to be elucidated. The goal of this review is to highlight the most recent findings and theories behind the role of non-coding RNAs (ncRNAs) in CRC.Recent FindingsRecent work has indicated that ncRNAs, RNA molecules that are not translated into protein, play significant roles in cellular events directly affecting CRC cell proliferation, migration, invasion, and survival. These ncRNAs include specific microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and other types of RNAs. Many of these molecules themselves are oncogenic or tumor suppressive in nature, and some have been suggested to be diagnostic and/or prognostic biomarkers in CRC. NcRNAs can impact gene expression and signal transduction through various mechanisms on epigenetic, transcriptional, post-transcriptional, translational, and post-translational levels.SummaryUnderstanding the biological mechanisms governing CRC initiation and propagation may lead to novel therapeutics and biomarkers for treating this deadly disease.
CONCLUSIONS: outpatient study did not reduce the quality of care and did not delay treatment. PMID: 31729234 [PubMed - as supplied by publisher]
We describe the principal mechanisms of resistance to anti-VEGF therapy and discuss potential biomarkers to be investigated in the near future.
Publication date: Available online 16 November 2019Source: Cancer EpidemiologyAuthor(s): Donata Linkeviciute-Ulinskiene, Audrius Dulskas, Ausvydas Patasius, Lina Zabuliene, Vincas Urbonas, Giedre Smailyte
CONCLUSIONS: Considering the age group in which rectal prolapse is most commonly seen, and the change in bowel habits, chronic constipation and irritation chronic seen in rectal prolapse may be responsible for the development of rectum cancer, therefore endoscopic screening should not be overlooked in rectal prolapse cases. KEY WORDS: Anorectal emergencies, Colon cancer, Rectal prolapse. PMID: 31723051 [PubMed - in process]
Authors: Grothey A, Marshall JL, Bekaii-Saab T PMID: 31730592 [PubMed - in process]
Authors: Grothey A PMID: 31730591 [PubMed - in process]
Authors: Bekaii-Saab T PMID: 31730590 [PubMed - in process]
Authors: Marshall JL PMID: 31730589 [PubMed - in process]
Authors: Grothey A, Marshall JL, Bekaii-Saab T Abstract The standard treatment for patients with metastatic colorectal cancer (mCRC) in the first- and second-line setting is generally chemotherapy, which can be augmented with vascular endothelial growth factor-targeted therapies and, for patients with KRAS wild-type status, epidermal growth factor receptor-targeted therapies. However, nearly all patients ultimately develop disease progression and require later lines of therapy. Traditionally, physicians recycled chemotherapy in the later lines, with many patients showing diminished or no response. However, the past...
Publication date: Available online 16 November 2019Source: Journal of Advanced ResearchAuthor(s): Chi-Cheng Huang, Ming-Hung Shen, Shao-Kuan Chen, Shung-Haur Yang, Chih-Yi Liu, Jiun-Wen Guo, Kang-Wei Chang, Chi-Jung HuangAbstractTumor metastasis or recurrence often occurs in patients with curative resection of colorectal cancer (CRC). Placental-specific 8 (PLAC8), which has increased expression in stool, may be associated with CRC recurrence. Insights into the role of PLAC8 in CRC recurrence and its clinical significance may support to develop strategies for preventing CRC recurrence and deterioration. Clinical tissues, ce...