GSE80729 Genome wide analysis of BCL3 mediated chemotherapy resistance

Contributors : Longtao Wu ; Kirk Cahill ; Bakhtiar YaminiSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe identify the atypical inhibitor- κB protein, Bcl3, as a novel biomarker in gliomas whose expression level predicts response to therapy. Bcl3 is found at 19q13 and its expression level in glioma is regulated by copy number alteration. Mechanistically, Bcl3 mediates mesenchymal differentiation and its presence promotes resistance to cytotoxic DNA damage.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research