Differential effects of high-fat diet and exercise training on bone and energy metabolism

Bone microarchitecture and strength are impaired by obesity and physical inactivity, but the underlying molecular regulation of bone metabolism in response to these factors is not well understood. Therefore, we analyzed bone and energy metabolism in male mice fed a high-fat or standard chow diet for 12  weeks with or without free access to running wheels.High-fat diet (HFD) mimicked the human condition of obesity and insulin resistance, including symptoms such as elevated serum glucose and insulin levels and reduced insulin-stimulated glucose uptake into muscle and adipose tissue.

Source: Bone - July 20, 2018 Category: Orthopaedics Authors: Ann-Kristin Picke, Lykke Sylow, Lisbeth L.V. M øller, Rasmus Kjøbsted, Felix N. Schmidt, Mikkel Wermer Steejn, Juliane Salbach-Hirsch, Christine Hofbauer, Matthias Blüher, Anja Saalbach, Björn Busse, Martina Rauner, Lorenz C. Hofbauer Tags: Full Length Article Source Type: research