Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder

Conclusions: This finding may imply greater organization of the CAB with increasing PTSD severity. The CAB connects directly to the cingulate cortex and the hippocampal subiculum, critical nodes of the default mode network, as well as being implicated in neurodegeneration pathology, decision-making, and executive functions, which may help explain previously shown alterations in this network in PTSD.Message of the Paper: Further study of white matter tract integrity in PTSD is warranted, particularly to investigate whether the CAB connections with both higher-order cognitive functioning and emotion processing regions contribute to the pathophysiology and comorbidity of PTSD.Mol Neuropsychiatry 2018;4:75 –82
Source: Molecular Neuropsychiatry - Category: Neuroscience Source Type: research