Encoding deficits in low-educated individuals with non-amnestic Mild Cognitive Impairment. Analysis of memory processes using the Item Specific Deficit Approach

Pure Alzheimer's Disease (AD) pathology has been recognized as the most frequent underlying pathology in non-amnestic Mild Cognitive Impairment (naMCI) (Schneider  et al., 2009). Supporting this data, Dugger et al. (2015) found that neurofibrillary tangles, neuritic plaques and Lewy Bodies loads were similar in persons with amnestic MCI (aMCI) and naMCI, with the temporal lobe showing a differential propensity of neurofibrillary tangles for aMCI and of L ewy-type alpha-synucleinopathy for naMCI. Conversely, naMCI has been associated with cerebrovascular disease more often than aMCI (Hughes et al., 2011), and it has been reported that naMCI patients are more likely to progress to other forms of dementia than AD (Ferman et al., 2013).
Source: Psychiatry Research - Category: Psychiatry Authors: Source Type: research