Iris melanoma in a child simulating juvenile xanthogranuloma

Jerry A Shields, Carol L Shields, Sara E Lally, Tatyana Milman, Ralph C EagleMiddle East African Journal of Ophthalmology 2018 25(2):115-117 An 8-year-old girl was referred for an amelanotic iris tumor believed to have enlarged slightly over 3 months, suspicious for juvenile xanthogranuloma (JXG). The affected right eye had a lightly pigmented, vascular iris mass measuring 6 mm in basal dimension and 2 mm in thickness. There were no feeder vessels, seeding, inflammatory cells, or cutaneous abnormalities. Diagnostic fine needle aspiration biopsy (FNAB) was performed, revealing spindle B melanoma cells that were immunoreactive for melanocytic markers HMB45 and Melan-A. Complete tumor resection by basal sector iridectomy was performed. Histopathology confirmed spindle B melanoma. At 14-years follow up, there has been no recurrence or metastasis and visual acuity remains 20/25. Iris melanoma can develop in children and clinically resemble nodular JXG.
Source: Middle East African Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research