Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq.

This study also reiterates previous findings that chemical-induced transcriptomic alterations occur prior to cytotoxicity and that transcriptomics provides in depth mechanistic information of the effects of chemicals on cellular transcriptional responses. TempO-Seq is a robust transcriptomic platform that is well suited for in vitro toxicity experiments. PMID: 30008028 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30008028?dopt=Abstract

Source: Archives of Toxicology - July 14, 2018 Category: Toxicology Authors: Limonciel A, Ates G, Carta G, Wilmes A, Watzele M, Shepard PJ, VanSteenhouse HC, Seligmann B, Yeakley JM, van de Water B, Vinken M, Jennings P Tags: Arch Toxicol Source Type: research