Botox Injection for Laryngeal Dysfunction in Alexander Disease

Alexander disease (AD) is a rare neurodegenerative disorder caused by mutations in the gene encoding the glial fibrillary acidic protein (GFAP).1 AD was first described in an infant in 19492,3 and characterized by the presence of Rosenthal fibers (RFs) —eosinophilic inclusions localized in astrocytic cytoplasms—found in perivascular, periventricular, and subpial spaces of the cerebral hemispheres, the cerebellum, and the brainstem.4 Brainstem involvement may cause otorhinolaryngologic manifestations, including dysphonia, dysphagia, tremulous v oice, nasal dysarthria, and palatal tremor (PT).
Source: Journal of Voice - Category: ENT & OMF Authors: Source Type: research