Increased costimulatory molecule expression of thymic and peripheral B cells and a sensitivity to IL-21 in myasthenia gravis

In this study, we investigated costimulatory molecules on B cells in the blood and in the thymus as well as by TLR9 and IL-21 stimulations in AChR+ MG patients with or without immunosuppressive treatment and controls.CD80 and CD86 expression on B cells was increased in the peripheral blood and in the thymus of untreated patients. CD86 was further amplified by IL-21.

Source: Journal of Neuroimmunology - July 15, 2018 Category: Allergy & Immunology Authors: Mehmet Hocao ğlu, Hacer Durmuş, Berker Özkan, Sibel P. Yentür, Öner Doğan, Yeşim Parman, Feza Deymeer, Güher Saruhan-Direskeneli Source Type: research