Regulatory T cells and CD20+ B cells in pediatric very severe aplastic anemia: possible clinical markers for evaluating the therapeutic efficacy and prognosis.

CONCLUSION: There is a moderate negative correlation between the percentage of Tregs and CD20+ B cells in our study. Our results shed light on the roles of Tregs and CD20+ B cells as therapeutic efficacy and prognostic markers of pediatric VSAA. Moreover, the mechanism underlying the decrease of blood Tregs and increase of CD20+ B cells in pediatric VSAA patients have been discussed, indicating that Tregs may suppress B cell responses. PMID: 29996743 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29996743?dopt=Abstract

Source: Hematology - July 13, 2018 Category: Hematology Tags: Hematology Source Type: research