Chronic Myeloid Leukemia Following Treatment for Primary Neoplasms or Other Medical Conditions: A Report of 21 Cases and Review of the Literature.

Conclusions: Therapy-related CML has a clinical presentation, pathologic features, and cytogenetic profile akin to de novo CML. Absence of additional significant aberrations seems to suggest a pathogenesis different from therapy-related AML/MDS. Therapy-related CML exhibits a robust therapeutic response to imatinib/derivatives and favorable clinical outcomes similar to de novo CML.
PMID: 29992292 [PubMed - as supplied by publisher]

Source: American Journal of Clinical Pathology - July 9, 2018 Category: Pathology Authors: Yang LH, Su P, Luedke C, Lu CM, Louissaint A, McCall CM, Rapisardo S, Vallangeon B, Wang E Tags: Am J Clin Pathol Source Type: research