Clinical efficacy of once-daily micronized purified flavonoid fraction 1000  mg tablet in patients with symptomatic chronic venous disease.

Clinical efficacy of once-daily micronized purified flavonoid fraction 1000 mg tablet in patients with symptomatic chronic venous disease. Curr Med Res Opin. 2018 Jul 11;:1-15 Authors: Kirienko A, Radak D, Maggioli A Abstract AIM: To investigate the clinical efficacy of micronized purified flavonoid fraction (MPFF) 1000 mg given as a single 1000 mg tablet once daily in patients suffering from chronic venous disease (CVD) versus MPFF 500 mg twice daily. METHODS: In an international, randomized, double-blind, parallel-group study, patients classified C0s to C4 according to Clinical Etiological Anatomic Pathophysiologic [CEAP] classification and with leg pain graded as superior to 4 cm on a 10-cm visual analog scale (VAS), were treated for 8 weeks with either MPFF 1000 mg once daily or MPFF 500 mg twice daily. The present post-hoc analysis focuses on the effect of treatment over time in patients randomized to the MPFF 1000 mg group. Leg pain was assessed at each follow-up visit by VAS. VAS scores over time were compared between in each visit using paired Student t tests. RESULTS: 87 patients over 174 were randomized to the MPFF 1000 mg group. Mean age (± SD) was 49.1±12.2 years, most of the patients were female (81.6%), the main CEAP classes of the most affected leg were C1 (20.7%), C2 (39.1%), C3 (33.33%) and the mean duration of CVD was 14.6±10.9 years. Patients wit...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research

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Publication date: October 2018Source: The Annals of Thoracic Surgery, Volume 106, Issue 4Author(s): Donna May Kimmaliardjuk, Carole Dennie, Sean Dickie, Eric C. Belanger, Fraser RubensA 29-year-old man with chronic pulmonary emboli presented to the hospital with progressive pleuritic chest pain. He was in acute right ventricular failure and received intrapulmonary arterial tissue plasminogen activator. Massive hemoptysis developed, requiring emergent thromboendarterectomy. A clot was visualized in the main left pulmonary artery that had formed a bronchovascular fistula into the left upper lobe bronchus. Pathology of the cl...
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