Fertility treatment does not appear to raise serious cancer risk

Small higher risk of non-invasive breast and ovarian tumours may not be due to treatment Related items fromOnMedica Only a third of women with regular bloating would see their GP Infertility much more likely after childhood cancer Unprotected sex among British teens – soars Experts call for wider HPV vaccination Use of contraceptive pill may lead to longer life
Source: OnMedica Latest News - Category: UK Health Source Type: news

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Many survivors of childhood cancer will experience premature gonadal insufficiency or infertility as a consequence of their medical treatments. Ovarian tissue cryopreservation (OTC) remains an experimental means of fertility preservation with few reports focused on the surgical technique and postoperative outcomes for OTC in children.
Source: Journal of Pediatric Surgery - Category: Surgery Authors: Source Type: research
AbstractAdult survivors of childhood cancers are more prone to developing poor reproductive and obstetrical outcomes than their siblings and the general population as a result of previous exposure to chemotherapy and radiation during childhood. Chemotherapy drugs exert cytotoxic effects systemically and therefore can damage the ovaries, leading to infertility, premature ovarian failure, and, to a lesser extent, spontaneous abortions. They have very limited or no deleterious effects on the uterus that can be recognized clinically. By contrast, radiation is detrimental to both the ovaries and the uterus, thereby causing a gr...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Review, Gynecologic Oncology Source Type: research
UCLA researchers have made new inroads into understanding germ cell tumors, a diverse and rare group of cancers that begin in germ cells — the cells that develop into sperm and eggs. The researchers developed a protocol to recreate germ cell tumor cells from stem cells and used the new model to study the genetics of the cancer.Their findings could point the way toward new drugs to treat germ cell tumors, which account for around 3 percent of all cases of childhood and adolescent cancer.The study, published in Stem Cell Research, was led by Amander Clark, a UCLA professor of molecular cell and developmental biology an...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Abstract Adult survivors of childhood cancers are more prone to developing poor reproductive and obstetrical outcomes than their siblings and the general population as a result of previous exposure to chemotherapy and radiation during childhood. Chemotherapy drugs exert cytotoxic effects systemically and therefore can damage the ovaries, leading to infertility, premature ovarian failure, and, to a lesser extent, spontaneous abortions. They have very limited or no deleterious effects on the uterus that can be recognized clinically. By contrast, radiation is detrimental to both the ovaries and the uterus, thereby ca...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
Survival rates for childhood cancer have dramatically increased due to advances in therapy, however, infertility often results from treatment. Experimental OTC may help prepubertal females and young women preserve their fertility. The purpose of this study was to explore the decision-making influences, perceived level of control over decision-making, and mood-states of patients and parents who were offered OTC prior to gonadotoxic therapy.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
Conclusion: To address the many challenges posed by EDCs, we argue that Africans should take the lead in prioritization and evaluation of environmental hazards, including EDCs. We recommend the institution of education and training programs for chemical users, adoption of the precautionary principle, establishment of biomonitoring programs, and funding of community-based epidemiology and wildlife research programs led and funded by African institutes and private companies. https://doi.org/10.1289/EHP1774 Received: 16 February 2017 Revised: 22 May 2017 Accepted: 24 May 2017 Published: 22 August 2017 Address correspond...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentary Source Type: research
This study shows that lifespan-extending conditions can slow molecular changes associated with an epigenetic clock in mice livers. Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging "clock", a robust biomarker of aging. However, while genetic, dietary and drug interventions can extend lifespan, their impact on the epigenome is uncharacterised. To fill this knowledge gap, we defined...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The increasing incidence of childhood cancers, coupled with improved overall survival rates has resulted in a growing cohort of reproductive aged survivors. Many cancer treatments are gonadotoxic and can lead to infertility and premature ovarian insufficiency (POI). The most established technique for fertility preservation (FP) is controlled ovarian hyperstimulation (COH) for the purpose of oocyte or embryo cryopreservation. However, COH poses 3 important issues: 1) possible delay in initiating treatment; 2) ovarian stimulation is impossible in pre-pubertal girls; and 3) discomfort with the transvaginal approach.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
(Abstracted from Fertil Steril 2016;106:1757–1762) Over the last several decades, the late-effect mortality from all causes has significantly decreased among 5-year survivors of childhood cancer. This increased survival is largely due to the development of effective chemotherapeutic regimens and radiotherapy.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: Gynecology: Infertility/Reproductive Technologies Source Type: research
This is a guest post from a very thoughtful patient of ours.It describes very eloquently the worries and fears which prey on an infertile patient's mind. It's very hard to discuss them with anyone, and bottling them up just makes things worse !--------------------------------------------------------------------------------------------------------------------------Isn't it a paradox that when India and world's population is exploding at alarming rate; here I am ,struggling to have a single child for 5 long years and with no idea when the struggle will really end.I am being treated at Malpani's and yesterday the doctor urged...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
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