Effects of multi and selective targeted tyrosine kinase inhibitors on function and signaling of different bladder cancer cells

ConclusionRTK and EMT related transcript analysis separate bladder cancer cells in two clusters. Functional responses towards TKI258 and BGJ398 treatment of bladder Fcancer cells were heterogeneous with deviating effects on signaling and possibly different therapeutic outcome.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research

Related Links:

CONCLUSIONS: OV6 could be a helpful indicator of disease progression and prognosis for BCa patients, and targeting the autocrine YAP/TEAD1/PDGF-BB/PDGFR loop might serve as a remedy for cis-platinum resistance in patients with advanced BCa. PMID: 30397177 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
In conclusion, the present findings demonstrated that the knockdown of lncRNA MALAT1 inhibits the proliferation and migration of BC cells by modulating the miR‑34a/CCND1 axis, suggesting that the MALAT1/miR‑34a/CCND1 axis may be a potential therapeutic target for BC treatment. PMID: 30387807 [PubMed - as supplied by publisher]
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
This study aims to study the biological role of miR-454-3p and miR-374b-5p in bladder cancer. The expression levels of miR-454-3p and miR-374b-5p were detected in BCa tissues and cell lines by qRT-PCR analysis. Kaplan-Meier analysis revealed that the expression levels of miR-454-3p and miR-374b-5p were positively correlated with the overall survival rate of BCa patients. Gain-of-function assays were conducted to demonstrate the inhibitory effects of miR-454-3p and miR-374b-5p on the invasion, migration and epithelial-mesenchymal transition (EMT) of BCa cells. Mechanically, ZEB2 was found to be a target of both miR-454-3p a...
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research
ConclusionOur findings suggest that CD44 expression is positively associated with tumor aggressiveness in bladder cancer, and activated IL-6 signaling provides a suitable microenvironment for the induction of CD44 expression.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: CircPRMT5 exerts critical roles in promoting UCB cells EMT and/or aggressiveness and is a prognostic biomarker of the disease, suggesting that circPRMT5 may serve as an exploitable therapeutic target for UCB patients. PMID: 30305293 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
Publication date: December 2018Source: Biomedicine &Pharmacotherapy, Volume 108Author(s): Yuelong Zhang, Dahong Zhang, Jia Lv, Shuai Wang, Qi ZhangAbstractMicroRNAs (miRNAs) have been widely studied in various human cancers, including bladder cancer. Previous report revealed that miR-125a-5p is downregulated in urothelial carcinomas. However, the biological function and molecular mechanism of miR-125a-5p in bladder cancer has not been elucidated. Therefore, this study focused on the role of miR-125a-5p in bladder cancer. The expression levels of miR-125a-5p were firstly tested in one normal cell line and four bladder c...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Abstract Epithelial-mesenchymal transition (EMT) is a biological process during which cells lose their characteristic structure and biochemical properties then adopt typical features of a mesenchymal phenotype. Alterations in the morphology, structure, and mechanical properties of cells during EMT are associated with a series of pathological processes. In this work, atomic force microscopy (AFM) is used for investigating effects of TGF-β1 on morphology and mechanical properties of living bladder cancer cells (T24) during EMT for the first time. High-resolution topography and Young's modulus images of T24 livi...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
guez L, Ferreira JA Abstract Circulating tumour cells (CTCs) originating from a primary tumour, lymph nodes and distant metastases hold great potential for liquid biopsies by providing a molecular fingerprint for disease dissemination and its temporal evolution through the course of disease management. CTC enumeration, classically defined on the basis of surface expression of Epithelial Cell Adhesion Molecule (EpCAM) and absence of the pan-leukocyte marker CD45, has been shown to correlate with clinical outcome. However, existing approaches introduce bias into the subsets of captured CTCs, which may exclude biolog...
Source: New Biotechnology - Category: Biotechnology Authors: Tags: N Biotechnol Source Type: research
Abstract Leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) is a transmembrane protein that antagonizes epidermal growth factor receptor (EGFR) signaling in epithelial tissues. Lrig1 is down-regulated in various epithelial cancers including bladder, breast, and colorectal cancer, suggesting that it functions as a tumor suppressor. However, its role in gastric carcinogenesis is not well understood. Here, we investigated the changes in Lrig1 expression during the stages of gastric cancer. We used a DMP-777-induced mouse spasmolytic polypeptide-expressing metaplasia (SPEM) model and tissue array of human ...
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research
Fujimoto Chiho Ohbayashi The nucleus accumbens-associated protein 1 (NACC1) is a transcription factor constitutively expressed in the urothelium, where it regulates cell growth, senescence, autophagy, and epithelial-mesenchymal transition. microRNA (miRNA) constitutes a class of small non-coding RNAs which are involved in cell proliferation, differentiation, and progression of tumors. miRNAs and their target molecules are utilized for molecular diagnosis of urothelial carcinoma. NACC1 is one of several putative target molecules of miR-331-3p, and is associated with cell proliferation in cancers such as prostate and ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
More News: Bladder Cancer | Cancer | Cancer & Oncology | Drugs & Pharmacology | Epithelial Cancer