Cognitive Behavioral Therapy for antipsychotic-free schizophrenia spectrum disorders: Does therapy dose influence outcome?

This study investigated the effect of “dose” and the components of Cognitive Behavioral Therapy (CBT) on treatment effects. It is a secondary analysis of the ACTION (Assessment of Cognitive Therapy Instead of Neuroleptics) trial which investigated CBT for people with schizophrenia spectrum disorders that chose not to take antipsycho tic medication. Using instrumental variable methods, we found a “dose-response” such that each CBT session attended, reduced the primary outcome measure (the PANSS total score) by approximately 0.6 points (95% CI −1.20 to −0.06, p = 0.031).
Source: Schizophrenia Research - Category: Psychiatry Authors: Source Type: research

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Authors: Guo ZH, Li ZJ, Ma Y, Sun J, Guo JH, Li WX, Wang ZQ, Xu HL, Ng RMK, Turkington D, Kingdon D PMID: 30221619 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
Abstract Psychological treatments are increasingly regarded as useful interventions for schizophrenia. However, a comprehensive evaluation of the available evidence is lacking and the benefit of psychological interventions for patients with current positive symptoms is still debated. The present study aimed to evaluate the efficacy, acceptability and tolerability of psychological treatments for positive symptoms of schizophrenia by applying a network meta-analysis approach, that can integrate direct and indirect comparisons. We searched EMBASE, MEDLINE, PsycINFO, PubMed, BIOSIS, Cochrane Library, World Health Orga...
Source: World Psychiatry - Category: Psychiatry Authors: Tags: World Psychiatry Source Type: research
Suicide rates are high and have only been increasing over the years. Over 800,000 people die all over the world by suicide each year. A proportion of the suicides are murder suicides resulting in additional loss of life. Attempts at suicide occur more frequently and we have about one million suicide attempts occurring each year. Suicide is a heart-breaking problem that is growing and needs to be addressed in as many ways as is possible. Understanding the risk factors, knowing the warning signs and what to do about them, is a crucial step. The more the awareness the greater the impact on suicide prevention. Risk Factors f...
Source: Psych Central - Category: Psychiatry Authors: Tags: Depression General Suicide Source Type: news
This study was prospectively registered, number ISRCTN99672552. The trial is closed to accrual.FindingsFrom Jan 1, 2013, to May 31, 2015, we randomly assigned 487 participants to either CBT and treatment as usual (n=242) or treatment as usual alone (n=245). Analysis included 209 in the CBT group and 216 in the treatment as usual group. No difference occurred in the primary outcome (PANSS total at 21 months, mean difference −0·89, 95% CI −3·32 to 1·55; p=0·48), although the CBT group improved at the end of treatment (PANSS total at 9 months, mean difference −2·40, −...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
Authors: Tréhout M, Dollfus S Abstract Schizophrenia is a severe chronic mental disorder that mainly manifests by positive symptoms, negative symptoms, disorganized behavior and thought and cognitive impairments. Taken together, these symptoms have substantial impact on quality of life, well-being and functional outcome. Patients with schizophrenia have dramatically higher levels of cardiovascular and metabolic morbidity than the general population due to poor physical fitness and to sedentary lifestyle. They have a reduced life expectancy, and an excess mortality being two or three times more than that in t...
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
CONCLUSIONS: Both interventions, in spite of some differences of efficacy, can be considered an important contribution to improve the patients' real-world functioning. Implications for rehabilitation Our study confirmed the need to include a set of psychosocial interventions for patients with schizophrenia spectrum disorders among usual treatment modalities. Techniques such as Befriending and Art therapy can be considered an important contribution to the treatment instruments required by the new community model for mental health. Befriending was found superior to Art therapy (between group effect) in improving psychosocial...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
Source: PharmacoEconomics and Outcomes News - Category: Drugs & Pharmacology Source Type: news
Over the past two decades, recovery, not just symptom control, has become the focus of treatment for individuals suffering from the various clinical challenges associated with the schizophrenia syndrome. While pharmacotherapy is standard practice for managing the disorder, it has clear limitations for achieving the outcomes that patients urgently need to regain social and vocational functioning. Effective treatments for negative symptoms, persistent psychotic symptoms, and neuro- and social cognitive impairments remain major unmet needs, which prevent optimal functional outcomes and impede the recovery of a significant pro...
Source: Schizophrenia Research - Category: Psychiatry Authors: Source Type: research
The Journal of Forensic Practice, Ahead of Print. Purpose The purpose of this paper is to identify the psychosocial approaches that have been studied and for which positive outcomes have been reported for individuals with schizophrenia in correctional and forensic psychiatric settings. Design/methodology/approach A rapid review of the literature was undertaken. A search was conducted on MEDLINE and PsycNET electronic databases. Each identified approach was analyzed to define their types and components. Findings In total, 24 studies pertaining to 18 different psychosocial approaches were identified. Half of the studies used...
Source: Journal of Forensic Practice - Category: Forensic Medicine Source Type: research
Condition:   Schizophrenia Spectrum and Other Psychotic Disorders Interventions:   Behavioral: Cognitive Behavior Therapy;   Behavioral: Acceptance and Commitment Therapy Sponsors:   Karolinska Institutet;   Stockholm County Council, Sweden Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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