Zirconium metal-organic framework nanocrystal as microwave sensitizer for enhancement of tumor therapy

Publication date: Available online 11 June 2018Source: Chinese Chemical LettersAuthor(s): Yuanwen Zou, Wei Zhang, Hongqiao Zhou, Changhui Fu, Longfei Tan, Zhongbing Huang, Xiangling Ren, Jun Ren, Xudong Chen, Xianwei MengAbstractAlthough surgical resection and chemotherapy were widely applied in tumor therapy, the dysfunction of normal cells resulted in the side effects (such as anorexia, nausea). MW thermal therapy is a non-invasive anticancer strategy under the help of MW sensitizer, with the safety and higher efficacy. Zirconium metal-organic framework nanocubes (ZrMOF NCs) modified with polyethylene glycol, were prepared via one pot method and carbodiimide technique, resulting in their large specific surface area and porosity. Our results showed that non-ion-loaded ZrMOF NCs in 0.9% NaCl solution exhibited better heating effect, higher than that in pure water, due to the robust collision among the ions under MW irradiation. The in vivo experiments confirmed that ZrMOF-PEG NCs + MW group exhibited the higher temperature in the tumor region than that of only MW treatment, suggesting a better MW thermal therapeutic anticancer efficacy. This work provides a new preparation strategy of biosafety nanomaterial as MW sensitizer for enhancing MW thermal anticancer therapy.Graphical abstractA microwave thermal therapy was proposed based on the strategy of microwave sensitizers and the susceptibility of the tumor tissue for enhancing thermal antitumor therapy.
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research