The Bowman ’s shield: a tribute to translational science and Detlef Schlöndorff

Crescentic glomerulonephritis is commonly characterized by prominent lymphocytic infiltration in and around Bowman ’s space. Previous studies have established a pathogenic role for CD4+ T cells in experimental crescentic glomerulonephritis, but the role of infiltrating cytotoxic CD8+ T cells has been difficult to elucidate. Although earlier studies suggested that CD8+ T-cell depletion ameliorates experimental glomerulonephritis,1,2 the injection of podocyte-specific CD8+ T cells failed to induce glomerulonephritis in healthy mice.

Source: Kidney International - July 10, 2018 Category: Urology & Nephrology Authors: David Harris, Christina M. Wyatt, Agnes B. Fogo, Pierre Ronco Tags: Nephrology Digest Source Type: research