Morbidity, mortality, and long-term consequences associated with diarrhoea from Cryptosporidium infection in children younger than 5 years: a meta-analyses study

Publication date: July 2018Source: The Lancet Global Health, Volume 6, Issue 7Author(s): Ibrahim A Khalil, Christopher Troeger, Puja C Rao, Brigette F Blacker, Alexandria Brown, Thomas G Brewer, Danny V Colombara, Eugenio L De Hostos, Cyril Engmann, Richard L Guerrant, Rashidul Haque, Eric R Houpt, Gagandeep Kang, Poonum S Korpe, Karen L Kotloff, Aldo A M Lima, William A Petri, James A Platts-Mills, David A Shoultz, Mohammed H ForouzanfarSummaryBackgroundThe protozoan Cryptosporidium is a leading cause of diarrhoea morbidity and mortality in children younger than 5 years. However, the true global burden of Cryptosporidium infection in children younger than 5 years might have been underestimated in previous quantifications because it only took account of the acute effects of diarrhoea. We aimed to demonstrate whether there is a causal relation between Cryptosporidium and childhood growth and, if so, to quantify the associated additional burden.MethodsThe Global Burden of Diseases, Injuries, and Risk Factors study (GBD) 2016 was a systematic and scientific effort to quantify the morbidity and mortality associated with more than 300 causes of death and disability, including diarrhoea caused by Cryptosporidium infection. We supplemented estimates on the burden of Cryptosporidium in GBD 2016 with findings from a systematic review of published and unpublished cohort studies and a meta-analysis of the effect of childhood diarrhoea caused by Cryptosporidium infection on physical grow...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research