Anti-Inflammatory, Antiapoptotic and Proproliferative Effects of Vitis vinifera Seed Ethanolic Extract in the Liver of Streptozotocin-Nicotinamide-Induced Type 2 Diabetes in Male Rats

ConclusionsThe anti-inflammatory, anti-apoptotic and pro-proliferative effects of VVSEE could account for its hepatoprotective actions in diabetes.RésuméObjectifsIl a été établi que la consommation de pépins de raisin de l‘espèce Vitis vinifera améliore la pathologie du foie lors de diabète sucré. Toutefois, on ignore les mécanismes à l'origine de ses effets. Dans la présente étude, les effets anti-inflammatoires, anti-apoptotiques et pro-prolifératifs de l'extrait éthanolique des pépins de raisin de l'espèce V. vinifera (EÉPVV) sur le foie des personnes atteintes du diabète ont été établis.MéthodesDes rats mâles adultes ayant un diabète induit par injection de streptozotocine et de nicotinamide ont reçu 50, 100 ou 200 mg/kg de poids corporel d'EÉPVV par voie orale durant 28 jours. À la fin du traitement, le poids corporel des rats a été déterminé et leur sang prélevé pour mesurer la glycémie à jeun, les concentrations d'insuline et des enzymes hépatiques. Après avoir abattu les souris, leur foie a été prélevé pour en mesurer le poids et le contenu en glycogène. Les apparences histologiques des foies ont été observées sous microscopie optiqu...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research

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Authors: Al-Rawahi A PMID: 32489679 [PubMed]
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Authors: Yahaya TO, Ufuoma SB Abstract Single gene mutations have been implicated in the pathogenesis of a form of diabetes mellitus (DM) known as the maturity-onset diabetes of the young (MODY). However, there are diverse opinions on the suspect genes and pathophysiology, necessitating the need to review and communicate the genes to raise public awareness. We used the Google search engine to retrieve relevant information from reputable sources such as PubMed and Google Scholar. We identified 14 classified MODY genes as well as three new and unclassified genes linked with MODY. These genes are fundamentally embedde...
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Publication date: Available online 3 June 2020Source: Pharmacological ResearchAuthor(s): Peyman Nowrouzi-Sohrabi, Reza Tabrizi, Shahla Rezaei, Fatemeh Jafari, Kamran Hesami, Mehdi Abedi, Mohammad Jalali, Pedram Keshavarzi, Saeed Shahabi, Ali Asghar Kolahi, Kristin Carson-Chahhoud, Amirhossein Sahebkar, Saeid Safiri
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Cardiovascular disease (CVD) is a major contributor to the morbidity and mortality associated with type 2 diabetes mellitus (T2DM). With T2DM growing in pandemic proportions, there will be profound healthcare implications of CVD in person with diabetes. The ideal drugs to improve outcomes in T2DM are those having antiglycemic efficacy in addition to cardiovascular (CV) safety, which has to be determined in appropriately designed CV outcome trials as mandated by regulatory agencies. Available evidence is largely supportive of metformin’s CV safety and potential CVD risk reduction effects, whereas sulfonylureas are eit...
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research
Conditions:   Diabetes Mellitus, Type 2;   Cognitive Dysfunction Interventions:   Behavioral: Tai Chi Chuan;   Behavioral: Fitness Walking;   Behavioral: Standard Diabetic Care Education Sponsors:   Jing Tao;   Second Affiliated Hospital of Heilongjiang University of Chinese Medicine;   Bao'an District People's Hospital of Shenzhen;   Xiyuan Hospital of China Academy of Chinese Medical Sciences;   Peking University;   University of Electronic Science and Technology of Ch...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This report places C. albidus on the growing number of disseminated mycosis-causing agents in diabetic patients. PMID: 32491141 [PubMed - as supplied by publisher]
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
CONCLUSIONS: This pilot study demonstrated an improved medication reconciliation process with pharmacist involvement, expanding the body of evidence that pharmacists can enhance TOC management in an inpatient setting. These results highlight the utility of a pharmacist in the implementation and refinement of TOC services and provides impetus for a team-based approach when patients experience a TOC. PMID: 32483643 [PubMed - in process]
Source: Southern Medical Journal - Category: General Medicine Tags: South Med J Source Type: research
ConclusionsA 5-year retrospective analysis reveals the mean prevalence of DR in the population with type 1 and type 2 DM in Poland was rather low.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
ConclusionsThe treatment with vildagliptin can be useful in controlling the renal complications of type 2 diabetes mellitus through inhibiting lipid peroxidation and increasing the antioxidant enzymes.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
To determine the pooled association between variations of prolactin serum levels within the physiological range and the risk of type 2 diabetes mellitus (T2D).
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
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