Dynamic < sup > 18 < /sup > F-FLT PET imaging of spatiotemporal changes in tumor cell proliferation and vasculature reveals the mechanistic actions of anti-angiogenic therapy.

Conclusions: Imaging with dynamic 18F-FLT PET revealed new insights relating to the interplay of vascular and proliferative pharmacodynamics of axitinib therapy, facilitating a greater understanding of the mechanistic actions of VEGFR-TKIs. Increases in tumor vasculature and cell proliferation during VEGFR-TKI treatment breaks, suggests this period is an optimal time to schedule synergistic chemotherapy and warrants further investigation. &#13. PMID: 29978839 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29978839?dopt=Abstract

Source: Physics in Medicine and Biology - July 6, 2018 Category: Physics Authors: Scarpelli M, Simoncic U, Perlman S, Liu G, Jeraj R Tags: Phys Med Biol Source Type: research