Bovine papilloma: aetiology, pathology, immunology, disease status, diagnosis, control, prevention and treatment: a review

In conclusion, this review focused on the aetiology, viral structure pathogenicity, transmission, macroscopic and microscopic pathology, pathogenesis, immunology, gene products, prevention, treatment and control of this virus in affected animal species.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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In conclusion, this study demonstrates the concept of combining docetaxel with the biodegradable microparticles at the point of care is technically feasible for achieving an effective drug-device combination tissue scaffold. This approach could provide an effective new approach for delivering adjuvant chemotherapy following radical prostatectomy. PMID: 31735095 [PubMed - in process]
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
In this study, a redox-sensitive CPT-OA conjugate containing the disulfide bond (CPT-SS-OA) was used to deliver the lactone-stabilized CPT for the improved antitumor efficacy. A non-sensitive CPT-OA was used as control to illuminate the role of disulfide bond. Both CPT-SS-OA and CPT-OA formulated in cremophor EL micelles (CM) displayed multiple therapeutic advantages: small diameter (∼14 nm), efficient cellular internalization, prolonged blood circulation, and favorable biodistribution. However, only CPT-SS-OA/CM achieved the superior chemotherapeutic efficacy over CPT solution in the Lewis lung carcinoma (LLC) cancer ...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Authors: Zan Y, Dai Z, Liang L, Deng Y, Dong L Abstract Sorafenib (SOR) is a multi-kinase inhibitor that was approved as the first-line systematic treatment agent of hepatocellular carcinoma (HCC). However, the anti-cancerous effect of SOR is dramatically impaired by the drug resistance, insufficient accumulation at tumor tissues, and limited tumor inner penetration. To combat the above issues, the PLA-based nanoparticles were first fabricated and co-loaded with SOR and plantamajoside (PMS), natural herbal medicines that possess excellent anti-cancerous effect on many types of drug resistant cancers. Then, the poly...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Authors: Fang W, Peng ZL, Dai YJ, Wang DL, Huang P, Huang HP Abstract Realgar and (-)-Epigallocatechin-3-gallate (EGCG) are natural medicines that inhibit cancer cell growth, resulting in inhibition of formation and development of tumors. The anticancer effects of realgar and EGCG were greatly improved following formulation as nanoparticles. EGCG has received increased attention as a drug carrier. The aim of this study was to prepare a new nanomedicine, (EGCG-RNPs), in which encapsulated nano-realgar. EGCG-RNPs were prepared by coprecipitation and characterized by transmission electron microscopy (TEM), differentia...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Abstract Discriminative identification of homologous miRNAs in miRNA family with high specificity and sensitivity is crucial for accurate classification, diagnosis and prognosis of breast cancer. Herein, we report a reliable, sensitive, and selective assay by coupling fluorescence resonance energy transfer (FRET) with cascade signal amplification. The strategy is developed by designing two programmable DNA probes that can be triggered to shift from "off" to "on" state in a cascade hybridization reaction in the presence of target miRNA let-7a, leading to the generation of an amplified signal. Th...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Abstract Single nucleotide polymorphism (SNP) was associated with many human diseases, therefore, SNP detection was important for early diagnosis and clinical prognosis. Herein, a simple and accurate method for visual detection SNP sites (A/A, G/G, A/G) in CYP1A1 gene related to cancers based on colloidal gold nucleic acid strip biosensor and primer-specific polymerase chain reaction (PCR) was established. This method could directly distinguish SNP sites on strip biosensor by introducing twice PCR amplifications. The second PCR (primer-specific PCR) was performed using specific product of the first PCR as template...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Abstract Nowadays, heterocyclic compounds act as a scaffold and are the backbone of medicinal chemistry. Among all of the heterocyclic scaffolds, 1,4-Dihydropyridine (1,4-DHP) is one of the most important heterocyclic rings that possess prominent therapeutic effects in a very versatile manner and plays an important role in synthetic, medicinal, and bioorganic chemistry. The main aim of the study is to review and encompass relevant studies related to 1,4-DHP and excellent therapeutic benefits of its derivatives. An extensive review of Pubmed-Medline, Embase and Lancet's published articles was done to find all relev...
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Tags: Mini Rev Med Chem Source Type: research
Exogeneous hyperthermia, defined as a 30 –60 minute exposure to a thermal stimulus of 40–44 °C, has been employed in treatment of an array of diseases [1]. This technique has proved effective in the treatment of various of cancers such as cervical, bladder and head and neck cancer [2–4]. Within our clinic we have used local hype rthermia at 44 ± 0.1 °C in the treatment of plantar warts and found this procedure to be more effective than that of conventional therapies [5,6]. With this method, we have also successfully alleviated cutaneous warts in patients with diabetes mellitus [7]...
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
Experts are still debating whether women need a pelvic exam at their yearly visit to a gynecologist, according to a new report. The report comes from a government-appointed expert panel that reviewed hundreds of studies on pelvic exams and concluded that there isn’t enough evidence to make a recommendation either for or against pelvic exams for women who don’t have symptoms of gynecologic conditions and aren’t pregnant. The panel, known as the U.S. Preventive Services Task Force (USPSTF), said that more studies are needed to better assess the potential benefits and harms of routine pelvic exams. In the me...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Mary shared her story of how she learned–on her own, at first–that foods that raise blood sugar, such as grains, cause you to “need” diabetes drugs. Not eating foods that raise blood sugar causes you to not need diabetes drugs. “I started going grain-free in December, 2014 as a last-ditch effort to get a handle on my diabetes. “My extreme reaction to metformin–stomach problems from diarrhea to esophageal spasms–made me give it up for good early last year. My blood sugars were out of control, but my doctor did not want to start me on insulin. My blood sugar numbers were regu...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Success Stories blood sugar diabetes gluten grains Weight Loss Source Type: blogs
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