Infertility, Not Fertility Drugs, Linked to Raised Risk of Ovarian Cancer

FRIDAY, July 6, 2018 -- Fertility drugs do not increase a woman's risk of ovarian cancer, a new study suggests. It did find that infertility itself is associated with an increased risk of ovarian cancer. The researchers examined data from more than...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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In this study, we reviewed major human studies on the health risks of radiation exposure and showed that sex-related factors may potentially influence the long-term response to radiation exposure. Available data suggest that long-term radiosensitivity in women is higher than that in men who receive a comparable dose of radiation. The report on the biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences, United States emphasized that women may be at significantly greater risk of suffering and dying from radiation-induced cancer than men exposed to the same dose of radiation....
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Xiao Wang and Haja N. Kadarmideen* Quantitative Genomics, Bioinformatics and Computational Biology Group, Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark Epigenetic changes are important for understanding complex trait variation and inheritance in pigs that are also a valuable biomedical model for human health research. Testis is the main organ for reproduction and boar taint in pigs; however, there have been no studies to-date on adult pig testis epigenome. The main objective of this study was to establish a genome-wide DNA methylation map of pig t...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Gui-Jiang Wei1,2, Ming-Qing Yuan1, Li-He Jiang1, Yu-Lan Lu3, Chun-Hong Liu3, Hong-Cheng Luo3, Hua-Tuo Huang3, Zong-Quan Qi1* and Ye-Sheng Wei1,2* 1Department of Cell Biology, Medical College of Guangxi University, Nanning, China 2Department of Medical Laboratory, Affiliated Hospital of Guilin Medical University, Guilin, China 3Department of Medical Laboratory, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China miRNAs are small non-coding RNAs modulating gene expression, and variants in miRNA genes are involved in the pathogenesis of ischemic stroke (IS). However, the effect of mi...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Authors: Bulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi L, Liu S, Kohlmeier A, Yin P, Milad M, Wei J Abstract Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pelvic pain in women and is associated with infertility. The underlying pathologic mechanisms in the intracavitary endometrium and extra-uterine endometriotic tissue involve defectively progr...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
In this study, vaginal microbiome was divided in five biotypes, being four of them dominated by lactobacilli and considered as healthy (pH 5.0) and higher diversity. In a healthy status, microbiota is balanced and forms a stable ecological unit dominated by Lactobacillus species, which fixes pH below 5.0 and controls non-desirable groups. In a pathogenic process, the microbiome shifts to a dysbiotic state, in which lactobacilli drop, pH is increased to values above 4.5 and other groups such as Gardnerella, Atopobium, Prevotella, and Streptococcus, among others, can overgrow (Srinivasan et al., 2012). Short chain fatty acid...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
This study evaluated the association between BRCA mutation status and serum anti-Müllerian hormone (AMH) level in young, reproductive-aged patients with breast cancer. Materials and Methods: Patients ≤ 40 years of age with breast cancer and who had known BRCA status and baseline serum AMH level at Samsung Medical Center, Seoul, Korea, were considered for inclusion. A total of 52 BRCA mutation carriers (27 BRCA1 and 25 BRCA2) and 264 non-carriers were selected for analyses. The serum level of AMH was compared according to presence of a BRCA mutation, and linear and logistic regression analyses were performed to eva...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
It is predicted that by 2030 the number of new cancer cases per year will rise to 23.6 million. As the number of cancer patients rises, so does the number of survivors whose quality of life is impacted by infertility. While the use of follicular stimulating hormone (FSH) and luteinizing hormone (LH) has not proven to be harmful to female cancer patients, cancer treatment itself may be gonadotoxic. Therefore, patients facing a cancer diagnosis can preserve future fertility through embryo or oocyte cryopreservation.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster Presentation Source Type: research
Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy affecting reproductive aged women. However, it is often underdiagnosed. Given the long-term health risks associated with PCOS, such as infertility, diabetes, and endometrial cancer, it is important to optimize accurate diagnosis. A self-reported questionnaire that identifies women who should undergo clinical screening for PCOS could reduce the number of women who go undiagnosed and untreated and would also facilitate research on risk factors for this condition.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster Presentation Source Type: research
CONCLUSION: Based on identified interactome, it is plausible that HE4 plays a crucial role in fertilization, specifically in sperm maturation, motility and capacitation. PMID: 30919767 [PubMed - as supplied by publisher]
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Tags: Protein Pept Lett Source Type: research
CONCLUSIONS: The EAOC patients were often diagnosed at a younger age, an earlier stage, and related to nulliparity and infertility. Patients with EAOC had a better prognosis than non-EAOC, early stage rather than association with endometriosis may be the driver of survival. PMID: 30913953 [PubMed - as supplied by publisher]
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Tags: Cancer Biol Ther Source Type: research
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